TY - JOUR
T1 - Synuclein-One study
T2 - Skin biopsy detection of phosphorylated α-synuclein for diagnosis of synucleinopathies
AU - Gibbons, Christopher H.
AU - Freeman, Roy
AU - Bellaire, Bailey
AU - Adler, Charles H.
AU - Moore, Dan
AU - Levine, Todd
N1 - Publisher Copyright:
© 2022 Future Medicine Ltd.
PY - 2022/5
Y1 - 2022/5
N2 - Finding an easily accessible and reliable tool to diagnose the diseases collectively defined as asynucleinopathies' is an urgent, unmet priority. The synucleinopathies include Parkinson's disease, multiple system atrophy, pure autonomic failure and dementia with Lewy bodies. There are millions of people who have a diagnosis of a synucleinopathy, with more diagnosed every year. With accessibility, ease of implementation, consistently high sensitivity (>80%) and specificity approaching 100%, skin biopsy has great potential as the clinical test of choice for the diagnosis of synucleinopathies. The large, multi-center Synuclein-One study will determine the sensitivity, specificity, accuracy and precision of α-synuclein detection within punch skin biopsies in patients with clinically established synucleinopathies using standardized, robust methods suitable for large-scale analysis. Clinical Trial Registration: NCT04700722 (ClinicalTrials.gov.
AB - Finding an easily accessible and reliable tool to diagnose the diseases collectively defined as asynucleinopathies' is an urgent, unmet priority. The synucleinopathies include Parkinson's disease, multiple system atrophy, pure autonomic failure and dementia with Lewy bodies. There are millions of people who have a diagnosis of a synucleinopathy, with more diagnosed every year. With accessibility, ease of implementation, consistently high sensitivity (>80%) and specificity approaching 100%, skin biopsy has great potential as the clinical test of choice for the diagnosis of synucleinopathies. The large, multi-center Synuclein-One study will determine the sensitivity, specificity, accuracy and precision of α-synuclein detection within punch skin biopsies in patients with clinically established synucleinopathies using standardized, robust methods suitable for large-scale analysis. Clinical Trial Registration: NCT04700722 (ClinicalTrials.gov.
KW - Parkinson's disease
KW - phosphorylated α-synuclein
KW - skin biopsy
KW - synucleinopathy
UR - http://www.scopus.com/inward/record.url?scp=85128160106&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85128160106&partnerID=8YFLogxK
U2 - 10.2217/bmm-2021-0646
DO - 10.2217/bmm-2021-0646
M3 - Article
C2 - 35272481
AN - SCOPUS:85128160106
SN - 1752-0363
VL - 16
SP - 499
EP - 509
JO - Biomarkers in Medicine
JF - Biomarkers in Medicine
IS - 7
ER -