Synthesis and Evaluation of Derivatives of the Proteasome Deubiquitinase Inhibitor b-AP15

Medicine & Life Sciences

• VLX1570 100%
• Deubiquitinating Enzymes 60%
• Proteasome Inhibitors 52%
• Proteasome Endopeptidase Complex 45%
• 3,5-bis((4-nitrophenyl)methylidene)-1-prop-2-enoylpiperidin-4-one 13%
• Ubiquitin 10%
• Catalytic Domain 9%
• Bortezomib 6%
• Structure-Activity Relationship 6%
• Enzyme Inhibitors 6%
• Solubility 5%
• Multiple Myeloma 5%
• Computer Simulation 5%
• Cysteine 5%
• Caspase 3 4%
• Phosphotransferases 4%
• Apoptosis 3%
• Therapeutics 2%
• In Vitro Techniques 2%
• Neoplasms 1%

Chemical Compounds

• Bortezomib 72%
• Enzyme Inhibitor 49%
• Cysteine Residue 45%
• Biological Property 42%
• Structure-Activity Relationship 37%
• Solubility 27%
• Probe 26%
• Aqueous Solution 22%
• Molecule 15%