TY - JOUR
T1 - Synthesis and characterizations of biodegradable and crosslinkable poly(ε-caprolactone fumarate), poly(ethylene glycol fumarate), and their amphiphilic copolymer
AU - Wang, Shanfeng
AU - Lu, Lichun
AU - Gruetzmacher, James A.
AU - Currier, Bradford L.
AU - Yaszemski, Michael J.
N1 - Funding Information:
This work was funded by the Mayo Foundation and National Institutes of Health (R01 AR45871 and R01 EB003060).
PY - 2006/2
Y1 - 2006/2
N2 - A series of self-crosslinkable and biodegradable polymers, poly(caprolactone fumarate) (PCLF), poly(ethylene glycol fumarate) (PEGF), and their copolymer PEGF-co-PCLF, has been developed for tissue engineering applications using a novel synthesis method. The current method employs potassium carbonate (K2CO3), other than the previously reported triethylamine, as the proton scavenger. The new synthetic route is more convenient and less time-consuming to carry out, and the synthesized polymers have a much lighter color, which renders them more suitable for self-crosslinking via photo-initiation. This group of polymers are essentially copolymers of fumaryl chloride, which contains double bonds for in situ crosslinking, with poly(ε-caprolactone) (PCL) or/and poly(ethylene glycol) (PEG) that has a flexible chain to facilitate self-crosslinking. Both PCLF and PEGF, and their amphiphilic copolymer PEGF-co-PCLF could be self-crosslinked or photocrosslinked to produce scaffolds without the use of a crosslinking agent. Our results suggest that these polymers are potentially useful as injectable, self-crosslinkable, and photo-crosslinkable materials for diverse tissue engineering applications.
AB - A series of self-crosslinkable and biodegradable polymers, poly(caprolactone fumarate) (PCLF), poly(ethylene glycol fumarate) (PEGF), and their copolymer PEGF-co-PCLF, has been developed for tissue engineering applications using a novel synthesis method. The current method employs potassium carbonate (K2CO3), other than the previously reported triethylamine, as the proton scavenger. The new synthetic route is more convenient and less time-consuming to carry out, and the synthesized polymers have a much lighter color, which renders them more suitable for self-crosslinking via photo-initiation. This group of polymers are essentially copolymers of fumaryl chloride, which contains double bonds for in situ crosslinking, with poly(ε-caprolactone) (PCL) or/and poly(ethylene glycol) (PEG) that has a flexible chain to facilitate self-crosslinking. Both PCLF and PEGF, and their amphiphilic copolymer PEGF-co-PCLF could be self-crosslinked or photocrosslinked to produce scaffolds without the use of a crosslinking agent. Our results suggest that these polymers are potentially useful as injectable, self-crosslinkable, and photo-crosslinkable materials for diverse tissue engineering applications.
KW - Amphiphilic polymer network
KW - Cross-linking
KW - Polycaprolactone
KW - Polyethylene oxide
KW - Polymerization
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UR - http://www.scopus.com/inward/citedby.url?scp=26944487609&partnerID=8YFLogxK
U2 - 10.1016/j.biomaterials.2005.07.013
DO - 10.1016/j.biomaterials.2005.07.013
M3 - Article
C2 - 16102819
AN - SCOPUS:26944487609
SN - 0142-9612
VL - 27
SP - 832
EP - 841
JO - Biomaterials
JF - Biomaterials
IS - 6
ER -