Synthesis and characterization of novel amphiphilic polymers as drug delivery nano carriers

Mukesh Pandey, Rahul Tyagi, Bhavna Gupta, Virinder S. Parmar, Jayant Kumar, Arthur C. Watterson

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Polymer nano-particles have been widely investigated in the last decade due to a variety of potential applications. In particular, polymers which can self assemble into micellar nano-particles can be effectively used as vehicles for drug delivery. Considerable efforts are underway to develop better drug delivery nano carriers for high drug loading capacity for a wide variety of bioactive compounds. In this study, several new polymers were synthesized in bulk (solventless condition) by a chemo-enzymatic methodology using Candida antarctica lipase B (Novozyme 435) and molecular sieves (MS). The synthesized polymers demonstrated high drug loading capacity and the potential to encapsulate drugs which are poorly soluble in aqueous solvents.

Original languageEnglish (US)
Pages (from-to)932-938
Number of pages7
JournalJournal of Macromolecular Science, Part A: Pure and Applied Chemistry
Volume45
Issue number11
DOIs
StatePublished - Nov 1 2008
Externally publishedYes

Fingerprint

Drug delivery
Polymers
Pharmaceutical Preparations
Candida
Molecular sieves
Lipases

Keywords

  • Amphiphilic polymer
  • Candida antarctica Lipase B
  • Chemo-enzymatic
  • Drug delivery
  • Encapsulation
  • Micelles
  • Nano-particles
  • Novozyme-435
  • Self-assembly
  • Static light scattering

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemistry(all)
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Synthesis and characterization of novel amphiphilic polymers as drug delivery nano carriers. / Pandey, Mukesh; Tyagi, Rahul; Gupta, Bhavna; Parmar, Virinder S.; Kumar, Jayant; Watterson, Arthur C.

In: Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, Vol. 45, No. 11, 01.11.2008, p. 932-938.

Research output: Contribution to journalArticle

Pandey, Mukesh ; Tyagi, Rahul ; Gupta, Bhavna ; Parmar, Virinder S. ; Kumar, Jayant ; Watterson, Arthur C. / Synthesis and characterization of novel amphiphilic polymers as drug delivery nano carriers. In: Journal of Macromolecular Science, Part A: Pure and Applied Chemistry. 2008 ; Vol. 45, No. 11. pp. 932-938.
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