Synthesis and characterization of novel amphiphilic polymers as drug delivery nano carriers

Mukesh K. Pandey; Rahul Tyagi; Bhavna Gupta; Virinder S. Parmar; Jayant Kumar; Arthur C. Watterson

doi:10.1080/10601320802380158

Synthesis and characterization of novel amphiphilic polymers as drug delivery nano carriers

Mukesh K. Pandey, Rahul Tyagi, Bhavna Gupta, Virinder S. Parmar, Jayant Kumar, Arthur C. Watterson

Radiology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Polymer nano-particles have been widely investigated in the last decade due to a variety of potential applications. In particular, polymers which can self assemble into micellar nano-particles can be effectively used as vehicles for drug delivery. Considerable efforts are underway to develop better drug delivery nano carriers for high drug loading capacity for a wide variety of bioactive compounds. In this study, several new polymers were synthesized in bulk (solventless condition) by a chemo-enzymatic methodology using Candida antarctica lipase B (Novozyme 435) and molecular sieves (MS). The synthesized polymers demonstrated high drug loading capacity and the potential to encapsulate drugs which are poorly soluble in aqueous solvents.

Original language	English (US)
Pages (from-to)	931-937
Number of pages	7
Journal	Journal of Macromolecular Science, Part A: Pure and Applied Chemistry
Volume	45
Issue number	11
DOIs	https://doi.org/10.1080/10601320802380158
State	Published - Nov 2008

Keywords

Amphiphilic polymer
Candida antarctica Lipase B
Chemo-enzymatic
Drug delivery
Encapsulation
Micelles
Nano-particles
Novozyme-435
Self-assembly
Static light scattering

ASJC Scopus subject areas

Ceramics and Composites
General Chemistry
Polymers and Plastics
Materials Chemistry

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10.1080/10601320802380158

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title = "Synthesis and characterization of novel amphiphilic polymers as drug delivery nano carriers",

abstract = "Polymer nano-particles have been widely investigated in the last decade due to a variety of potential applications. In particular, polymers which can self assemble into micellar nano-particles can be effectively used as vehicles for drug delivery. Considerable efforts are underway to develop better drug delivery nano carriers for high drug loading capacity for a wide variety of bioactive compounds. In this study, several new polymers were synthesized in bulk (solventless condition) by a chemo-enzymatic methodology using Candida antarctica lipase B (Novozyme 435) and molecular sieves (MS). The synthesized polymers demonstrated high drug loading capacity and the potential to encapsulate drugs which are poorly soluble in aqueous solvents.",

keywords = "Amphiphilic polymer, Candida antarctica Lipase B, Chemo-enzymatic, Drug delivery, Encapsulation, Micelles, Nano-particles, Novozyme-435, Self-assembly, Static light scattering",

author = "Pandey, {Mukesh K.} and Rahul Tyagi and Bhavna Gupta and Parmar, {Virinder S.} and Jayant Kumar and Watterson, {Arthur C.}",

note = "Funding Information: The authors gratefully acknowledge the financial support from the University of Massachusetts, Lowell, MA.",

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AU - Pandey, Mukesh K.

AU - Tyagi, Rahul

AU - Gupta, Bhavna

AU - Parmar, Virinder S.

AU - Kumar, Jayant

AU - Watterson, Arthur C.

N1 - Funding Information: The authors gratefully acknowledge the financial support from the University of Massachusetts, Lowell, MA.

PY - 2008/11

Y1 - 2008/11

N2 - Polymer nano-particles have been widely investigated in the last decade due to a variety of potential applications. In particular, polymers which can self assemble into micellar nano-particles can be effectively used as vehicles for drug delivery. Considerable efforts are underway to develop better drug delivery nano carriers for high drug loading capacity for a wide variety of bioactive compounds. In this study, several new polymers were synthesized in bulk (solventless condition) by a chemo-enzymatic methodology using Candida antarctica lipase B (Novozyme 435) and molecular sieves (MS). The synthesized polymers demonstrated high drug loading capacity and the potential to encapsulate drugs which are poorly soluble in aqueous solvents.

AB - Polymer nano-particles have been widely investigated in the last decade due to a variety of potential applications. In particular, polymers which can self assemble into micellar nano-particles can be effectively used as vehicles for drug delivery. Considerable efforts are underway to develop better drug delivery nano carriers for high drug loading capacity for a wide variety of bioactive compounds. In this study, several new polymers were synthesized in bulk (solventless condition) by a chemo-enzymatic methodology using Candida antarctica lipase B (Novozyme 435) and molecular sieves (MS). The synthesized polymers demonstrated high drug loading capacity and the potential to encapsulate drugs which are poorly soluble in aqueous solvents.

KW - Amphiphilic polymer

KW - Candida antarctica Lipase B

KW - Chemo-enzymatic

KW - Drug delivery

KW - Encapsulation

KW - Micelles

KW - Nano-particles

KW - Novozyme-435

KW - Self-assembly

KW - Static light scattering

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JF - Journal of Macromolecular Science, Part A: Pure and Applied Chemistry

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ER -

Synthesis and characterization of novel amphiphilic polymers as drug delivery nano carriers

Abstract

Keywords

ASJC Scopus subject areas

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