Synthesis and characterization of a block copolymer consisting of poly(propylene fumarate) and poly(ethylene glycol)

Laura J. Suggs, Richard G. Payne, Michael J. Yaszemski, Lawrence B. Alemany, Antonios G. Mikos

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Poly(propylene fumarate-co-ethylene glycol) has been synthesized in an effort to develop a cross-linkable biomaterial for use as a vascular implant. This copolymer has been fabricated in a block configuration with two to three homopolymer units in series through a transesterification reaction between the linear polyester and the terminal hydroxyl functionalities of the poly(ethylene glycol) (PEG). A number of design parameters including the molecular weights of the two homopolymers, the copolymer reaction time, and the weight percent of PEG were varied in order to assess their effects on the properties of the resulting copolymer. This material has been characterized in terms of structure and composition as well as thermal properties and solubility behavior. All formulations of the copolymer exhibited a single glass transition temperature and a single melting temperature, with a degree of crystallinity which was dependent upon the relative amount of PEG. The copolymers were water soluble and demonstrated enhanced solubilities in organic solvents compared to the parent homopolymere.

Original languageEnglish (US)
Pages (from-to)4318-4323
Number of pages6
JournalMacromolecules
Volume30
Issue number15
DOIs
StatePublished - Jul 28 1997

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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