Abstract
The synthesis and chemical resolution of cis-and trans-fused 8a-phenyldecahydroquinolines 3 and 4 are described together with the affinity of the four optically pure compounds for the PCP recognition site of the NMDA receptor complex. These compounds were also evaluated for their antagonistic effects on cGMP levels in male Swiss Webster mice, and (−)-4 was found to exhibit in vivo potency comparable to that of MK-801. The results of the binding studies are interpreted in terms of a preferred orientation of PCP's N-H bond in binding to its NMDA receptor-associated recognition site.
Original language | English (US) |
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Pages (from-to) | 1634-1638 |
Number of pages | 5 |
Journal | Journal of Medicinal Chemistry |
Volume | 35 |
Issue number | 9 |
DOIs | |
State | Published - May 1 1992 |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery