Synovial activation of chondrocytes: Evidence for complex cytokine interactions

G. Bandara, H. I. Georgescu, C. W. Lin, C. H. Evans

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Synoviocytes secrete factors which induce the synthesis of neutral metalloproteinases (NMP) and prostaglandin E2 (PGE2) by chondrocytes in a response called "chondrocyte activation". We analyzed synovial chondrocyte activating factors (CAF) for the presence of cytokines which modulated the NMP production by articular chondrocytes. These studies suggested the presence of several other cytokines in addition to interleukin-1 (IL-1). Both resting and activated synoviocytes contained mRNA for basic fibroblast growth factor (bFGF) which is a synergist for IL-1 induced NMP production, and secreted bFGF into their culture media. They also expressed mRNA for transforming growth factor β (TGF β) which inhibits IL-1 induced NMP production. These cells also produce tumor necrosis factor α (TNF α) and trace amounts of interleukin-6 (IL-6). In addition to these there is evidence for a synovial activator of chondrocytes which is distinct from IL-1. Since a number of recombinant cytokines including TNF α, IL-6 and bFGF failed to activate chondrocytes, this could be a novel cytokine.

Original languageEnglish (US)
Pages (from-to)285-288
Number of pages4
JournalAgents and Actions
Volume34
Issue number1-2
DOIs
StatePublished - Sep 1 1991

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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