Synergy of L-arginine and growth hormone (GH)-releasing peptide-2 on GH release: Influence of gender

Laurie Wideman, Judy Y. Weltman, James T. Patrie, C. Y. Bowers, Niki Shah, Shannon Story, Arthur Weltman, Johannes D. Veldhuis

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


We test the hypotheses that 1) growth hormone (GH)-releasing peptide-2 (G) synergizes with L-arginine (A), a compound putatively achieving selective somatostatin withdrawal and 2) gender modulates this synergy on GH secretion. To these ends, 18 young healthy volunteers (9 men and 9 early follicular phase women) each received separate morning intravenous infusions of saline (S) or A (30 g over 30 min) or G (1 μg/kg) or both, in randomly assigned order. Blood was sampled at 10-min intervals for later chemiluminescence assay of serum GH concentrations. Analysis of covariance revealed that the preinjection (basal) serum GH concentrations significantly determined secretagogue responsiveness and that sex (P = 0.02) and stimulus type (P < 0.001) determined the slope of this relationship. Nested ANOVA applied to log-transformed measures of GH release showed that gender determines 1) basal rates of GH secretion, 2) the magnitude of the GH secretory response to A, 3) the rapidity of attaining the GH maximum, and 4) the magnitude or fold (but not absolute) elevation in GH secretion above preinjection basal, as driven by the combination of A and G. In contrast, the emergence of the G and A synergy is sex independent. We conclude that gender modulates key facets of basal and A/G-stimulated GH secretion in young adults.

Original languageEnglish (US)
Pages (from-to)R1455-R1466
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number4 48-4
StatePublished - 2000


  • Endocrine
  • Female
  • Male
  • Pituitary
  • Regulation
  • Somatotropin

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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