Synergy of L-arginine and growth hormone (GH)-releasing peptide-2 on GH release: Influence of gender

Laurie Wideman, Judy Y. Weltman, James T. Patrie, C. Y. Bowers, Niki Shah, Shannon Story, Arthur Weltman, Johannes D Veldhuis

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We test the hypotheses that 1) growth hormone (GH)-releasing peptide-2 (G) synergizes with L-arginine (A), a compound putatively achieving selective somatostatin withdrawal and 2) gender modulates this synergy on GH secretion. To these ends, 18 young healthy volunteers (9 men and 9 early follicular phase women) each received separate morning intravenous infusions of saline (S) or A (30 g over 30 min) or G (1 μg/kg) or both, in randomly assigned order. Blood was sampled at 10-min intervals for later chemiluminescence assay of serum GH concentrations. Analysis of covariance revealed that the preinjection (basal) serum GH concentrations significantly determined secretagogue responsiveness and that sex (P = 0.02) and stimulus type (P < 0.001) determined the slope of this relationship. Nested ANOVA applied to log-transformed measures of GH release showed that gender determines 1) basal rates of GH secretion, 2) the magnitude of the GH secretory response to A, 3) the rapidity of attaining the GH maximum, and 4) the magnitude or fold (but not absolute) elevation in GH secretion above preinjection basal, as driven by the combination of A and G. In contrast, the emergence of the G and A synergy is sex independent. We conclude that gender modulates key facets of basal and A/G-stimulated GH secretion in young adults.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume279
Issue number4 48-4
StatePublished - 2000
Externally publishedYes

Fingerprint

Growth Hormone
Arginine
growth hormone-releasing peptide-2
Follicular Phase
Luminescence
Somatostatin
Serum
Intravenous Infusions
Young Adult
Analysis of Variance
Healthy Volunteers

Keywords

  • Endocrine
  • Female
  • Male
  • Pituitary
  • Regulation
  • Somatotropin

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Wideman, L., Weltman, J. Y., Patrie, J. T., Bowers, C. Y., Shah, N., Story, S., ... Veldhuis, J. D. (2000). Synergy of L-arginine and growth hormone (GH)-releasing peptide-2 on GH release: Influence of gender. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 279(4 48-4).

Synergy of L-arginine and growth hormone (GH)-releasing peptide-2 on GH release : Influence of gender. / Wideman, Laurie; Weltman, Judy Y.; Patrie, James T.; Bowers, C. Y.; Shah, Niki; Story, Shannon; Weltman, Arthur; Veldhuis, Johannes D.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 279, No. 4 48-4, 2000.

Research output: Contribution to journalArticle

Wideman, L, Weltman, JY, Patrie, JT, Bowers, CY, Shah, N, Story, S, Weltman, A & Veldhuis, JD 2000, 'Synergy of L-arginine and growth hormone (GH)-releasing peptide-2 on GH release: Influence of gender', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 279, no. 4 48-4.
Wideman, Laurie ; Weltman, Judy Y. ; Patrie, James T. ; Bowers, C. Y. ; Shah, Niki ; Story, Shannon ; Weltman, Arthur ; Veldhuis, Johannes D. / Synergy of L-arginine and growth hormone (GH)-releasing peptide-2 on GH release : Influence of gender. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2000 ; Vol. 279, No. 4 48-4.
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