Sympathetic responsiveness is not increased in women with a history of hypertensive pregnancy

Sushant M. Ranadive, Ronee E. Harvey, Brian D. Lahr, Virginia M Miller, Michael Joseph Joyner, Jill N. Barnes

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hypertensive pregnancy (HTNP) is a risk factor for future cardiovascular disease. Exaggerated cardiovascular responses to physical stress are also considered an independent marker of cardiovascular disease risk. However, there are limited data regarding the blood pressure (BP) responses to acute stress in women, who have a history of HTNP. Hence, the aim of the study is to compare BP responses to a physical stress in postmenopausal women with a history of HTNP to age-and parity-matched women with a history of normotensive pregnancy (NP). Beat-to-beat BP and heart rate was recorded in 64 postmenopausal women with [age = 58.5 (55.2, 62.2) yr, where values are the median, 25th percentile, and 75th percentile] and without [age = 59.4 (55.9, 62.4) yr] a history of HTNP before and during isometric handgrip (IHG) exercise (30% of maximal voluntary contraction) to fatigue. Muscle metaboreflex was measured during postexercise ischemia following IHG exercise. BP variables increased similarly in response to IHG exercise [systolic: NP = 11.5 (8.9, 17.6) %, HTNP = 11.3 (9.5, 15.9) %; diastolic NP = 11.2 (7.9, 13.3) %, HTNP = 9.5 (7.1, 14.3) %; mean blood pressure: NP = 9.8 (5.0, 13.6) %, and HTNP = 7.2 (4.4, 10.4) %] and postexercise ischemia [systolic: NP = 14.1 (10.3, 23.0) %, HTNP = 15.8 (10.6, 21.4) %; diastolic NP = 12.2 (4.8, 17.0) %, HTNP = 10.4 (5.3, 17.1) %; and mean blood pressure: NP = 11.1 (6.1, 17.9) %, HTNP = 9.4 (2.9, 14.8) %] in both groups. Although having a history of HTNP is associated with future cardiovascular disease risk, results from this study suggest that the risk may not be manifested through altered cardiovascular metaboreflex response to physical stressors.

Original languageEnglish (US)
Pages (from-to)R49-R54
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume312
Issue number1
DOIs
StatePublished - 2017

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Reproductive History
Pregnancy
Blood Pressure
Cardiovascular Diseases
Exercise
Ischemia
Parity
Fatigue

Keywords

  • Isometric handgrip exercise
  • Preeclampsia
  • Pressor response

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Sympathetic responsiveness is not increased in women with a history of hypertensive pregnancy. / Ranadive, Sushant M.; Harvey, Ronee E.; Lahr, Brian D.; Miller, Virginia M; Joyner, Michael Joseph; Barnes, Jill N.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 312, No. 1, 2017, p. R49-R54.

Research output: Contribution to journalArticle

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abstract = "Hypertensive pregnancy (HTNP) is a risk factor for future cardiovascular disease. Exaggerated cardiovascular responses to physical stress are also considered an independent marker of cardiovascular disease risk. However, there are limited data regarding the blood pressure (BP) responses to acute stress in women, who have a history of HTNP. Hence, the aim of the study is to compare BP responses to a physical stress in postmenopausal women with a history of HTNP to age-and parity-matched women with a history of normotensive pregnancy (NP). Beat-to-beat BP and heart rate was recorded in 64 postmenopausal women with [age = 58.5 (55.2, 62.2) yr, where values are the median, 25th percentile, and 75th percentile] and without [age = 59.4 (55.9, 62.4) yr] a history of HTNP before and during isometric handgrip (IHG) exercise (30{\%} of maximal voluntary contraction) to fatigue. Muscle metaboreflex was measured during postexercise ischemia following IHG exercise. BP variables increased similarly in response to IHG exercise [systolic: NP = 11.5 (8.9, 17.6) {\%}, HTNP = 11.3 (9.5, 15.9) {\%}; diastolic NP = 11.2 (7.9, 13.3) {\%}, HTNP = 9.5 (7.1, 14.3) {\%}; mean blood pressure: NP = 9.8 (5.0, 13.6) {\%}, and HTNP = 7.2 (4.4, 10.4) {\%}] and postexercise ischemia [systolic: NP = 14.1 (10.3, 23.0) {\%}, HTNP = 15.8 (10.6, 21.4) {\%}; diastolic NP = 12.2 (4.8, 17.0) {\%}, HTNP = 10.4 (5.3, 17.1) {\%}; and mean blood pressure: NP = 11.1 (6.1, 17.9) {\%}, HTNP = 9.4 (2.9, 14.8) {\%}] in both groups. Although having a history of HTNP is associated with future cardiovascular disease risk, results from this study suggest that the risk may not be manifested through altered cardiovascular metaboreflex response to physical stressors.",
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AU - Ranadive, Sushant M.

AU - Harvey, Ronee E.

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AU - Joyner, Michael Joseph

AU - Barnes, Jill N.

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