Sympathetic neural responses to smoking are age dependent

Dagmara Hering, Virend Somers, Tomas Kara, Wiestawa Kucharska, Pavel Jurak, Leszek Bieniaszewski, Krzysztof Narkiewicz

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: Smoking is an important risk factor for cardiovascular disease. Sympathetic responses to cigarette smoking may be implicated in the link between smoking and cardiovascular disease. We tested the hypothesis that the sympathetic neural responses to smoking are age dependent. Methods: We examined the effects of cigarette smoking and sham smoking on muscle sympathetic nerve activity, blood pressure and heart rate in 14 normotensive middle-aged (49 ± 4 years) and 12 young (29 ± 4 years) habitual smokers matched for body mass index (25 ± 2 kg/m 2 in both groups). Results: Sham smoking had no significant effect on sympathetic drive, blood pressure or heart rate in either group. Cigarette smoking increased heart rate in both middle-aged subjects and young subjects. In comparison to younger subjects, middle-aged smokers showed similar smoking-related increases in systolic blood pressure (SBP) [10 ± 3 versus 12 ± 2 mmHg, respectively, not significant (NS)]. Smoking decreased sympathetic nerve activity by 28 ± 12% of baseline values (P < 0.01) in young subjects. However, muscle sympathetic nerve activity did not change significantly after smoking in middle-aged subjects (5 ± 8%, NS), despite the increased blood pressures, which would be expected to inhibit sympathetic activity. By contrast, in young subjects, the heart rate increase (22 ± 2 bpm) was greater than that seen in middle-aged subjects (13 ± 2 bpm, P < 0.01). Conclusions: The autonomic responses to smoking are age dependent. While blood pressure increases are similar in both groups, young subjects respond to smoking by marked increases in heart rate and suppression of central sympathetic outflow. In middle-aged subjects, the heart rate increase is less marked, but sympathetic vasoconstrictor activity is not suppressed.

Original languageEnglish (US)
Pages (from-to)691-695
Number of pages5
JournalJournal of Hypertension
Volume24
Issue number4
DOIs
StatePublished - Apr 2006

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Smoking
Heart Rate
Blood Pressure
Cardiovascular Diseases
Muscles
Vasoconstrictor Agents
Body Mass Index

Keywords

  • Age
  • Cardiovascular disease
  • Heart rate
  • Smoking
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

Cite this

Hering, D., Somers, V., Kara, T., Kucharska, W., Jurak, P., Bieniaszewski, L., & Narkiewicz, K. (2006). Sympathetic neural responses to smoking are age dependent. Journal of Hypertension, 24(4), 691-695. https://doi.org/10.1097/01.hjh.0000217851.95583.57

Sympathetic neural responses to smoking are age dependent. / Hering, Dagmara; Somers, Virend; Kara, Tomas; Kucharska, Wiestawa; Jurak, Pavel; Bieniaszewski, Leszek; Narkiewicz, Krzysztof.

In: Journal of Hypertension, Vol. 24, No. 4, 04.2006, p. 691-695.

Research output: Contribution to journalArticle

Hering, D, Somers, V, Kara, T, Kucharska, W, Jurak, P, Bieniaszewski, L & Narkiewicz, K 2006, 'Sympathetic neural responses to smoking are age dependent', Journal of Hypertension, vol. 24, no. 4, pp. 691-695. https://doi.org/10.1097/01.hjh.0000217851.95583.57
Hering, Dagmara ; Somers, Virend ; Kara, Tomas ; Kucharska, Wiestawa ; Jurak, Pavel ; Bieniaszewski, Leszek ; Narkiewicz, Krzysztof. / Sympathetic neural responses to smoking are age dependent. In: Journal of Hypertension. 2006 ; Vol. 24, No. 4. pp. 691-695.
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abstract = "Objective: Smoking is an important risk factor for cardiovascular disease. Sympathetic responses to cigarette smoking may be implicated in the link between smoking and cardiovascular disease. We tested the hypothesis that the sympathetic neural responses to smoking are age dependent. Methods: We examined the effects of cigarette smoking and sham smoking on muscle sympathetic nerve activity, blood pressure and heart rate in 14 normotensive middle-aged (49 ± 4 years) and 12 young (29 ± 4 years) habitual smokers matched for body mass index (25 ± 2 kg/m 2 in both groups). Results: Sham smoking had no significant effect on sympathetic drive, blood pressure or heart rate in either group. Cigarette smoking increased heart rate in both middle-aged subjects and young subjects. In comparison to younger subjects, middle-aged smokers showed similar smoking-related increases in systolic blood pressure (SBP) [10 ± 3 versus 12 ± 2 mmHg, respectively, not significant (NS)]. Smoking decreased sympathetic nerve activity by 28 ± 12{\%} of baseline values (P < 0.01) in young subjects. However, muscle sympathetic nerve activity did not change significantly after smoking in middle-aged subjects (5 ± 8{\%}, NS), despite the increased blood pressures, which would be expected to inhibit sympathetic activity. By contrast, in young subjects, the heart rate increase (22 ± 2 bpm) was greater than that seen in middle-aged subjects (13 ± 2 bpm, P < 0.01). Conclusions: The autonomic responses to smoking are age dependent. While blood pressure increases are similar in both groups, young subjects respond to smoking by marked increases in heart rate and suppression of central sympathetic outflow. In middle-aged subjects, the heart rate increase is less marked, but sympathetic vasoconstrictor activity is not suppressed.",
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AU - Hering, Dagmara

AU - Somers, Virend

AU - Kara, Tomas

AU - Kucharska, Wiestawa

AU - Jurak, Pavel

AU - Bieniaszewski, Leszek

AU - Narkiewicz, Krzysztof

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N2 - Objective: Smoking is an important risk factor for cardiovascular disease. Sympathetic responses to cigarette smoking may be implicated in the link between smoking and cardiovascular disease. We tested the hypothesis that the sympathetic neural responses to smoking are age dependent. Methods: We examined the effects of cigarette smoking and sham smoking on muscle sympathetic nerve activity, blood pressure and heart rate in 14 normotensive middle-aged (49 ± 4 years) and 12 young (29 ± 4 years) habitual smokers matched for body mass index (25 ± 2 kg/m 2 in both groups). Results: Sham smoking had no significant effect on sympathetic drive, blood pressure or heart rate in either group. Cigarette smoking increased heart rate in both middle-aged subjects and young subjects. In comparison to younger subjects, middle-aged smokers showed similar smoking-related increases in systolic blood pressure (SBP) [10 ± 3 versus 12 ± 2 mmHg, respectively, not significant (NS)]. Smoking decreased sympathetic nerve activity by 28 ± 12% of baseline values (P < 0.01) in young subjects. However, muscle sympathetic nerve activity did not change significantly after smoking in middle-aged subjects (5 ± 8%, NS), despite the increased blood pressures, which would be expected to inhibit sympathetic activity. By contrast, in young subjects, the heart rate increase (22 ± 2 bpm) was greater than that seen in middle-aged subjects (13 ± 2 bpm, P < 0.01). Conclusions: The autonomic responses to smoking are age dependent. While blood pressure increases are similar in both groups, young subjects respond to smoking by marked increases in heart rate and suppression of central sympathetic outflow. In middle-aged subjects, the heart rate increase is less marked, but sympathetic vasoconstrictor activity is not suppressed.

AB - Objective: Smoking is an important risk factor for cardiovascular disease. Sympathetic responses to cigarette smoking may be implicated in the link between smoking and cardiovascular disease. We tested the hypothesis that the sympathetic neural responses to smoking are age dependent. Methods: We examined the effects of cigarette smoking and sham smoking on muscle sympathetic nerve activity, blood pressure and heart rate in 14 normotensive middle-aged (49 ± 4 years) and 12 young (29 ± 4 years) habitual smokers matched for body mass index (25 ± 2 kg/m 2 in both groups). Results: Sham smoking had no significant effect on sympathetic drive, blood pressure or heart rate in either group. Cigarette smoking increased heart rate in both middle-aged subjects and young subjects. In comparison to younger subjects, middle-aged smokers showed similar smoking-related increases in systolic blood pressure (SBP) [10 ± 3 versus 12 ± 2 mmHg, respectively, not significant (NS)]. Smoking decreased sympathetic nerve activity by 28 ± 12% of baseline values (P < 0.01) in young subjects. However, muscle sympathetic nerve activity did not change significantly after smoking in middle-aged subjects (5 ± 8%, NS), despite the increased blood pressures, which would be expected to inhibit sympathetic activity. By contrast, in young subjects, the heart rate increase (22 ± 2 bpm) was greater than that seen in middle-aged subjects (13 ± 2 bpm, P < 0.01). Conclusions: The autonomic responses to smoking are age dependent. While blood pressure increases are similar in both groups, young subjects respond to smoking by marked increases in heart rate and suppression of central sympathetic outflow. In middle-aged subjects, the heart rate increase is less marked, but sympathetic vasoconstrictor activity is not suppressed.

KW - Age

KW - Cardiovascular disease

KW - Heart rate

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KW - Sympathetic nervous system

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