Sympathetic neural outflow and chemoreflex sensitivity are related to spontaneous breathing rate in normal men

Krzysztof Narkiewicz, Philippe Van De Borne, Nicola Montano, Dagmara Hering, Tomas Kara, Virend Somers

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Respiration contributes importantly to short-term modulation of sympathetic nerve activity. However, the relationship between spontaneous breathing rate, chemoreflex function, and direct measures of sympathetic traffic in healthy humans has not been studied previously. We tested the hypothesis that muscle sympathetic nerve activity and chemoreflex sensitivity are linked independently to respiratory rate in normal subjects. We studied 69 normal male subjects aged 29.6±8.1 years. Subjects were subdivided according to the tertiles of respiratory rate distributions. Mean respiration rate was 10.6 breaths/min in the first tertile, 14.8 breaths/min in the second tertile, and 18.0 breaths/min in the third tertile. Subjects from the third tertile (faster respiratory rate) had greater sympathetic activity than subjects from the first tertile (slower respiratory rate; 29±3 versus 17±2 bursts/min; P<0.001). Stepwise multiple linear regression analysis revealed that only respiratory rate was linked independently to sympathetic activity (r=0.42; P<0.001). In comparison to subjects with slow respiratory rate, subjects with fast respiratory rate had greater increases in minute ventilation during both hypercapnia (7.3±0.8 versus 3.2±1.0 L/min; P=0.005) and hypoxia (5.7±0.8 versus 2.4±0.7 L/min; P=0.007). Muscle sympathetic nerve activity and chemoreflex sensitivity are linked to spontaneous respiratory rate in normal humans. Faster respiratory rate is associated with higher levels of sympathetic traffic and potentiated responses to hypoxia and hypercapnia. Spontaneous breathing frequency, central sympathetic outflow, and chemoreflex sensitivity exhibit significant and hitherto unrecognized interactions in the modulation of neural circulatory control.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
JournalHypertension
Volume47
Issue number1
DOIs
StatePublished - Jan 2006

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Respiratory Rate
Respiration
Hypercapnia
Muscles
Ventilation
Linear Models
Regression Analysis

Keywords

  • Autonomic nervous system
  • Blood pressure
  • Heart rate
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Sympathetic neural outflow and chemoreflex sensitivity are related to spontaneous breathing rate in normal men. / Narkiewicz, Krzysztof; Van De Borne, Philippe; Montano, Nicola; Hering, Dagmara; Kara, Tomas; Somers, Virend.

In: Hypertension, Vol. 47, No. 1, 01.2006, p. 51-55.

Research output: Contribution to journalArticle

Narkiewicz, Krzysztof ; Van De Borne, Philippe ; Montano, Nicola ; Hering, Dagmara ; Kara, Tomas ; Somers, Virend. / Sympathetic neural outflow and chemoreflex sensitivity are related to spontaneous breathing rate in normal men. In: Hypertension. 2006 ; Vol. 47, No. 1. pp. 51-55.
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