Switching the targeting pathways of a therapeutic antibody by nanodesign

Sanjib Bhattacharyya; Raman Deep Singh; Richard Pagano; J. David Robertson; Resham Bhattacharya; Priyabrata Mukherjee

doi:10.1002/anie.201105432

Switching the targeting pathways of a therapeutic antibody by nanodesign

Sanjib Bhattacharyya, Raman Deep Singh, Richard Pagano, J. David Robertson, Resham Bhattacharya, Priyabrata Mukherjee

Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

On the right path: The mechanisms of endocytosis of cetuximab (C225) and its nanoconjugates have been elucidated in a pancreatic cancer cell line. By using gold nanoparticles as a scaffold, it is possible to switch the pathway for endocytosis from a Dyn-2-dependent caveolar mechanism to Cdc42-dependent pinocytosis/phagocytosis. Tailoring endocytotic mechanisms may enable specific intracellular pathways to be targeted.

Original language	English (US)
Pages (from-to)	1563-1567
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	7
DOIs	https://doi.org/10.1002/anie.201105432
State	Published - Feb 13 2012

Keywords

drug delivery
endocytosis
gold
lipid microdomains
nanoparticles

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201105432

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AU - Mukherjee, Priyabrata

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Switching the targeting pathways of a therapeutic antibody by nanodesign

Abstract

Keywords

ASJC Scopus subject areas

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