Switching the targeting pathways of a therapeutic antibody by nanodesign

Sanjib Bhattacharyya, Raman Deep Singh, Richard Pagano, J. David Robertson, Resham Bhattacharya, Priyabrata Mukherjee

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

On the right path: The mechanisms of endocytosis of cetuximab (C225) and its nanoconjugates have been elucidated in a pancreatic cancer cell line. By using gold nanoparticles as a scaffold, it is possible to switch the pathway for endocytosis from a Dyn-2-dependent caveolar mechanism to Cdc42-dependent pinocytosis/phagocytosis. Tailoring endocytotic mechanisms may enable specific intracellular pathways to be targeted.

Original languageEnglish (US)
Pages (from-to)1563-1567
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number7
DOIs
StatePublished - Feb 13 2012

Keywords

  • drug delivery
  • endocytosis
  • gold
  • lipid microdomains
  • nanoparticles

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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