Survivorship in a population based cohort of patients with Sjogren's syndrome, 1976-1992

Peter B. Martens, Stanley R. Pillemer, Lennert T.H. Jacobsson, W. Michael O'Fallon, Eric L. Matteson

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Objective. Sjogren's syndrome (SS) has been associated with development of lymphoid malignancies and other significant medical complications, but the effect of SS on survival in a population based sample has not been reported. We analyzed survival in an incidence cohort of patients diagnosed with SS in residents of Olmsted County, Minnesota, USA, between 1976 and 1992. Methods. All records of physician diagnosed SS were reviewed, as well as all records from patients diagnosed with xerostomia and keratoconjunctivitis sicca, and records of patients with rheumatoid arthritis (RA) and systemic lupus erythematosus. The case definition for SS required 2 of 3 criteria: keratoconjunctivitis sicca, xerostomia, or serologic abnormality. Confounding illnesses were excluded. All patients were white. Results. Of the 74 cases of SS identified, 50 (67%) had primary SS and 24 (33%) secondary SS. An average of 7.2 years of followup was available for patients with primary SS and 9.9 years for patients with secondary SS. Compared with the general population, patients with SS had increased mortality (p = 0.04). When patients with primary and secondary SS were studied separately, increased mortality was found in patients with secondary SS (p < 0.005) but not primary SS (p = 0.86). Conclusion. In this population based cohort, patients with primary SS did not have increased mortality. However, mortality may have been increased in patients with secondary SS, the majority of whom had RA.

Original languageEnglish (US)
Pages (from-to)1296-1300
Number of pages5
JournalJournal of Rheumatology
Volume26
Issue number6
StatePublished - 1999

Keywords

  • Epidemiology
  • Mortality
  • Sjogren's syndrome

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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