Surgical considerations after chemotherapy and radiation therapy for inflammatory breast cancer

Charles D. Knight, J. Kirk Martin, John S. Welch, James N. Ingle, Thomas A. Gaffey, Alvaro Martinez

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Eighteen patients seen between 1974 and 1982 with the clinical diagnosis of inflammatory breast carcinoma underwent modified radical mastectomy after preoperative chemotherapy and radiation therapy. In 17 of the 18 patients (94%), residual carcinoma was detected in either the resected breast or the axillary nodes. All mastectomies were accomplished without major technical difficulty. Seven wound complications, including three infections, occurred. Local recurrence was noted in 29% (five of 17 patients) and distant metastasis was detected in 89% (16 of 18 patients). Only three patients are presently alive without evidence of disease 19, 21, and 21 months since the onset of symptoms. Eleven patients have died, the median survival being 23 months since the development of symptoms, and four are alive with distant metastasis. Modified radical mastectomy can be accomplished in patients with inflammatory breast cancer after preoperative chemotherapy and radiation therapy and may have a role in reducing local tumor burden.

Original languageEnglish (US)
Pages (from-to)385-391
Number of pages7
JournalSurgery
Volume99
Issue number4
StatePublished - 1986

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Inflammatory Breast Neoplasms
Radiotherapy
Drug Therapy
Modified Radical Mastectomy
Neoplasm Metastasis
Mastectomy
Tumor Burden
Breast
Carcinoma
Recurrence
Survival
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery

Cite this

Knight, C. D., Martin, J. K., Welch, J. S., Ingle, J. N., Gaffey, T. A., & Martinez, A. (1986). Surgical considerations after chemotherapy and radiation therapy for inflammatory breast cancer. Surgery, 99(4), 385-391.

Surgical considerations after chemotherapy and radiation therapy for inflammatory breast cancer. / Knight, Charles D.; Martin, J. Kirk; Welch, John S.; Ingle, James N.; Gaffey, Thomas A.; Martinez, Alvaro.

In: Surgery, Vol. 99, No. 4, 1986, p. 385-391.

Research output: Contribution to journalArticle

Knight, CD, Martin, JK, Welch, JS, Ingle, JN, Gaffey, TA & Martinez, A 1986, 'Surgical considerations after chemotherapy and radiation therapy for inflammatory breast cancer', Surgery, vol. 99, no. 4, pp. 385-391.
Knight CD, Martin JK, Welch JS, Ingle JN, Gaffey TA, Martinez A. Surgical considerations after chemotherapy and radiation therapy for inflammatory breast cancer. Surgery. 1986;99(4):385-391.
Knight, Charles D. ; Martin, J. Kirk ; Welch, John S. ; Ingle, James N. ; Gaffey, Thomas A. ; Martinez, Alvaro. / Surgical considerations after chemotherapy and radiation therapy for inflammatory breast cancer. In: Surgery. 1986 ; Vol. 99, No. 4. pp. 385-391.
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