Superiority of granisetron to dexamethasone plus prochlorperazine in the prevention of chemotherapy-induced emesis

David Warr, Andrew Willan, Sheldon Fine, Kenneth Wilson, Alan Davis, Charles Erlichman, James Rusthoven, Wycliffe Lofters, David Osoba, Francis Laberge, Jean Latreille, Joseph Pater

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Trials of selective 5-hydroxytrypta-mine3 receptor antagonists have shown excellent antiemetic activity for chemotherapy containing cisplatin when compared with high-dose metoclopramide. There is little information about the efficacy of these new agents for chemotherapy other than for high-dose cisplatin. We performed a double-blind, randomized trial comparing a single dose of the 5-hydroxytryptamine3 receptor antagonist granisetron (BRL 43694A) as a single intravenous dose with dexamethasone plus prochlorperazine in 152 patients receiving their first course of moderately emetogenic chemotherapy (mainly doxorubicin-and cyclophosphamide-containing combinations). During the first 24 hours, there was a statistically significant advantage for the granisetron group in terms of the prevention of both nausea and emesis. There was no difference in the frequency of reported adverse events. We conclude that granisetron is more effective than dexamethasone plus prochlorperazine in patients who are receiving moderately emetogenic cytotoxic agents. (J Natl Cancer Inst 83: 1169-1173, 1991)

Original languageEnglish (US)
Pages (from-to)1169-1173
Number of pages5
JournalJournal of the National Cancer Institute
Volume83
Issue number16
DOIs
StatePublished - Aug 21 1991

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Superiority of granisetron to dexamethasone plus prochlorperazine in the prevention of chemotherapy-induced emesis'. Together they form a unique fingerprint.

  • Cite this

    Warr, D., Willan, A., Fine, S., Wilson, K., Davis, A., Erlichman, C., Rusthoven, J., Lofters, W., Osoba, D., Laberge, F., Latreille, J., & Pater, J. (1991). Superiority of granisetron to dexamethasone plus prochlorperazine in the prevention of chemotherapy-induced emesis. Journal of the National Cancer Institute, 83(16), 1169-1173. https://doi.org/10.1093/jnci/83.16.1169