TY - JOUR
T1 - [18F]-fluorodeoxyglucose - Positron emission tomography in patients with active myelopathy
AU - Flanagan, Eoin P.
AU - Hunt, Christopher H.
AU - Lowe, Val
AU - Mandrekar, Jay
AU - Pittock, Sean J.
AU - O'Neill, Brian Patrick
AU - Keegan, B. Mark
N1 - Funding Information:
Potential Competing Interests: Dr O’Neill serves on scientific advisory committees of the V Foundation, Accelerate Brain Cancer Cure (ABC2), and the Sontag Foundation. He receives research support from the Mayo Foundation, ABC2, the National Cancer Institute, and the National Institute of Neurologic Disorders and Stroke. Dr Lowe serves on the scientific advisory board for Bayer Schering Pharma and receives research support from GE Healthcare, Siemens Molecular Imaging, AVID Radiopharmaceuticals, the National Institutes of Health (National Institute on Aging, National Cancer Institute), the MN Partnership for Biotechnology and Medical Genomics, and the Leukemia & Lymphoma Society. Dr Pittock is a named inventor on patents (no. 12/678,350 filed 2010 and no. 12/573,942 filed 2008) that relate to functional AQP4/NMO-IgG assays and NMO-IgG as a cancer marker; receives research support from Alexion Pharmaceuticals, Inc, the Guthy Jackson Charitable Foundation, and the National Institutes of Health. Dr Keegan has served as a consultant to Novartis, Bionest, and Bristol Meyers Squibb and has research funded by Terumo BCT.
PY - 2013/11
Y1 - 2013/11
N2 - Objective: To report and compare spinal cord [18F]- fluorodeoxyglucose - positron emission tomography (FDG-PET) metabolism in 51 patients with active myelopathy. Patients and Methods: We retrospectively identified patients from January 1, 2001, through December 31, 2011, with active myelopathy in whom FDG-PET was performed. Inclusion criteria were (1) intramedullary myelopathy, (2) neoplastic/inflammatory etiology, and (3) FDG-PET performed after myelopathy onset. Exclusion criteria were (1) extramedullary myelopathy, (2) radiation-associated myelopathy, (3) no pathological confirmation of neoplasm, and (4) inactive myelopathy. Diagnostic categories of nonsarcoid inflammatory, neoplastic, and neurosarcoid were based on their final myelopathic diagnosis. Two radiologists who independently assessed FDG-PET for spinal cord hypermetabolism and maximum standardized uptake value (SUVmax) were blinded to the underlying etiology. Results: Fifty-one patients (53% women) with a median age of 60 years (range, 20-82 years) were included. Inflammatory myelopathic diagnoses (n=24) were as follows: paraneoplastic (n=13), autoimmune/ other (n=5), inflammatory demyelinating (n=4), and transverse myelitis (n=2). Neoplastic diagnoses (n=21) were as follows: intramedullary metastases (n=12), intramedullary lymphoma/leukemia (n=7), and primary intramedullary neoplasm (n=2). Six patients had neurosarcoid myelopathy. Spinal cord hypermetabolism was more common with neoplastic myelopathy than with nonsarcoid inflammatory myelopathy (17 of 21 [81%] vs 6 of 24 [25%]; P<.001). Agreement between radiologist's assessments was excellent (κ=0.88). Median SUVmax was greater in neoplastic than in nonsarcoid inflammatory causes of myelopathy (3.3 g/mL vs 1.9 g/mL; P<.001). The FDG-PET hypermetabolism was seen in 3 of the 6 patients (50%) with neurosarcoid myelopathy (median SUVmax, 2.6 g/mL; range, 1.8-12.2 g/mL). Conclusion: Spinal cord FDG-PET hypermetabolism in patients with active myelopathy may be reliably detected and was more common in neoplastic than in inflammatory myelopathies in this study. Future investigation of spinal cord FDG-PET is indicated to assess its potential contributions in evaluating active myelopathies.
AB - Objective: To report and compare spinal cord [18F]- fluorodeoxyglucose - positron emission tomography (FDG-PET) metabolism in 51 patients with active myelopathy. Patients and Methods: We retrospectively identified patients from January 1, 2001, through December 31, 2011, with active myelopathy in whom FDG-PET was performed. Inclusion criteria were (1) intramedullary myelopathy, (2) neoplastic/inflammatory etiology, and (3) FDG-PET performed after myelopathy onset. Exclusion criteria were (1) extramedullary myelopathy, (2) radiation-associated myelopathy, (3) no pathological confirmation of neoplasm, and (4) inactive myelopathy. Diagnostic categories of nonsarcoid inflammatory, neoplastic, and neurosarcoid were based on their final myelopathic diagnosis. Two radiologists who independently assessed FDG-PET for spinal cord hypermetabolism and maximum standardized uptake value (SUVmax) were blinded to the underlying etiology. Results: Fifty-one patients (53% women) with a median age of 60 years (range, 20-82 years) were included. Inflammatory myelopathic diagnoses (n=24) were as follows: paraneoplastic (n=13), autoimmune/ other (n=5), inflammatory demyelinating (n=4), and transverse myelitis (n=2). Neoplastic diagnoses (n=21) were as follows: intramedullary metastases (n=12), intramedullary lymphoma/leukemia (n=7), and primary intramedullary neoplasm (n=2). Six patients had neurosarcoid myelopathy. Spinal cord hypermetabolism was more common with neoplastic myelopathy than with nonsarcoid inflammatory myelopathy (17 of 21 [81%] vs 6 of 24 [25%]; P<.001). Agreement between radiologist's assessments was excellent (κ=0.88). Median SUVmax was greater in neoplastic than in nonsarcoid inflammatory causes of myelopathy (3.3 g/mL vs 1.9 g/mL; P<.001). The FDG-PET hypermetabolism was seen in 3 of the 6 patients (50%) with neurosarcoid myelopathy (median SUVmax, 2.6 g/mL; range, 1.8-12.2 g/mL). Conclusion: Spinal cord FDG-PET hypermetabolism in patients with active myelopathy may be reliably detected and was more common in neoplastic than in inflammatory myelopathies in this study. Future investigation of spinal cord FDG-PET is indicated to assess its potential contributions in evaluating active myelopathies.
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U2 - 10.1016/j.mayocp.2013.07.019
DO - 10.1016/j.mayocp.2013.07.019
M3 - Article
C2 - 24182701
AN - SCOPUS:84888876901
SN - 0025-6196
VL - 88
SP - 1204
EP - 1212
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 11
ER -