@article{6e0b6e79958241c7b6ecf2c8a89a0479,
title = "18 F-AV-1451 uptake differs between dementia with lewy bodies and posterior cortical atrophy ",
abstract = " Background: Posterior cortical atrophy and dementia with Lewy bodies are 2 distinct clinical syndromes, yet they can overlap in symptoms and occipital hypometabolism. Patients with dementia with Lewy bodies often have overlapping Alzheimer's disease pathology. Similarly, Lewy bodies can be found in patients with posterior cortical atrophy. We investigated differences in the distribution and magnitude of F18-AV-1451 uptake in patients with these 2 syndromes. Methods: Consecutive patients with probable dementia with Lewy bodies (n = 33), posterior cortical atrophy (n = 18), and cognitively unimpaired controls (n = 100) underwent 18 F-AV-1451 positron emission tomography. Regional differences in AV-1451 uptake were assessed using voxel-wise and an atlas-based approach. The greatest differences in AV-1451 uptake between patient groups were identified using area under receiver operating curve statistics, and a composite region was derived. Results: AV-1451 uptake in both patient groups was predominantly localized to the lateral occipital regions, but the magnitude of uptake was markedly greater in posterior cortical atrophy compared with dementia with Lewy bodies. The posterior cortical atrophy group showed the greatest AV-1451 uptake throughout all the gray matter compared with that in other groups. The occipital composite region, consisting of superior, middle, and inferior occipital cortices, distinguished posterior cortical atrophy from dementia with Lewy bodies (area under the curve >0.97; P < 0.001, Bonferroni-corrected) with excellent sensitivity (88%) and specificity (100%). Conclusions: Posterior cortical atrophy and dementia with Lewy bodies can share clinical features, and although the pattern of AV-1451 uptake in occipital cortices overlaps between these 2 syndromes, its magnitude is significantly higher in posterior cortical atrophy.",
keywords = "F-AV-1451, dementia with Lewy bodies, occipital association cortex, posterior cortical atrophy, tau PET",
author = "Zuzana Nedelska and Josephs, {Keith A.} and Jonathan Graff-Radford and Przybelski, {Scott A.} and Lesnick, {Timothy G.} and Boeve, {Bradley F.} and Drubach, {Daniel A.} and Knopman, {David S.} and Petersen, {Ronald C.} and Jack, {Clifford R.} and Lowe, {Val J.} and Whitwell, {Jennifer L.} and Kejal Kantarci",
note = "Funding Information: Funding agencies: This study was supported by the National Institutes of Health (U01-NS100620, R01-AG050603, R21-NS094684, P50-AG016574, U01-AG006786, R01-AG011378, R01-AG041851, R01-AG040042, C06-RR018898, and R01-NS080820), Foundation Dr. Corinne Schuler, the Mangurian Foundation for Lewy Body Research, the Elsie and Marvin Dekelboum Family Foundation, and the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer{\textquoteright}s Disease Research Program. The sponsors played no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. Funding Information: The authors thank AVID Radiopharmaceuticals, Inc., for provision of AV-1451 precursor, chemistry production advice and oversight and FDA regulatory cross-filing permission and documentation needed for this work. Dr. Nedelska was supported by CTSA grant number UL1 TR002377 from the National Center for Advancing Translational Sciences (NCATS), a component of the NIH; its contents are solely the responsibility of the authors and do not necessarily represent the official view of NIH; and the IBRO-ISN research fellowship. Funding Information: Acknowledgments: The authors thank AVID Radiopharmaceuticals, Inc., for provision of AV-1451 precursor, chemistry production advice and oversight and FDA regulatory cross-filing permission and documentation needed for this work. Dr. Nedelska was supported by CTSA grant number UL1 TR002377 from the National Center for Advancing Translational Sciences (NCATS), a component of the NIH; its contents are solely the responsibility of the authors and do not necessarily represent the official view of NIH; and the IBRO-ISN research fellowship. Publisher Copyright: {\textcopyright} 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2019",
month = mar,
doi = "10.1002/mds.27603",
language = "English (US)",
volume = "34",
pages = "344--352",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "3",
}