Successful treatment with novel triple drug combination consisting of interferon-γ, interferon alfacon-1, and ribavirin in a nonresponder HCV patient to pegylated interferon therapy

Vijayan Balan, Marianne J. Rosati, Machiko H. Anderson, Jorge Rakela

Research output: Contribution to journalArticle

6 Scopus citations


Despite major advances in therapy of hepatitis C over the past decade, nearly half of the patients treated with the currently available regimens do not clear the virus. Therefore, there is a large unmet need for more effective therapy for patients who have failed pegylated interferon plus ribavirin therapy. We describe a case of a HCV genotype 1b patient who had failed previous combination therapies of interferon plus ribavirin and pegylated interferon plus ribavirin and was subsequently successfully treated with a novel triple drug combination consisting of interferon-γ plus interferon alfacon plus ribavirin with the outcome of a sustained virologic response. This triple drug therapy combination could be an option for patients who have failed therapies with currently available pegylated interferons plus ribavirin. Prospective randomized studies are required to evaluate the effectiveness and tolerability of this regimen in this patient population.

Original languageEnglish (US)
Pages (from-to)956-959
Number of pages4
JournalDigestive Diseases and Sciences
Issue number5
StatePublished - May 2006



  • Gamma interferon
  • Hepatitis C
  • Interferon alfacon
  • Nonresponder
  • Ribavirin

ASJC Scopus subject areas

  • Gastroenterology

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