Successful treatment of progressive multifocal leukoencephalopathy with low-dose interleukin-2

D. Przepiorka; K. A. Jaeckle; R. R. Birdwell; G. N. Fuller; A. J. Kumar; Y. O. Huh; I. McCutcheon

doi:10.1038/sj.bmt.1701010

Successful treatment of progressive multifocal leukoencephalopathy with low-dose interleukin-2

D. Przepiorka, K. A. Jaeckle, R. R. Birdwell, G. N. Fuller, A. J. Kumar, Y. O. Huh, I. McCutcheon

Neurology

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

A patient with low-grade lymphoma presented 8 months after autologous marrow transplantation with dizziness, aphasia and hemiparesis. Magnetic resonance imaging (MRI) showed an abnormal T2 signal in the frontoparietal region unilaterally. Biopsy of the area demonstrated progressive multifocal leukoencephalopathy positive for JC virus and p53. Treatment with interleukin-2 at 0.5 MU/m²/day i.v. continuous infusion resulted in near complete resolution of symptoms and MRI abnormalities. The absolute number of CD3⁺CD4⁺ and CD3^-CD56⁺ cells in the peripheral blood also increased, and the CD4/CD8 ratio normalized. She remains free of evidence of progressive multifocal leukoencephalopathy 1 year off therapy.

Original language	English (US)
Pages (from-to)	983-987
Number of pages	5
Journal	Bone Marrow Transplantation
Volume	20
Issue number	11
DOIs	https://doi.org/10.1038/sj.bmt.1701010
State	Published - Dec 1 1997

Keywords

Interleukin-2
JC virus
Progressive multifocal leukoencephalopathy
Treatment

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/sj.bmt.1701010

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title = "Successful treatment of progressive multifocal leukoencephalopathy with low-dose interleukin-2",

abstract = "A patient with low-grade lymphoma presented 8 months after autologous marrow transplantation with dizziness, aphasia and hemiparesis. Magnetic resonance imaging (MRI) showed an abnormal T2 signal in the frontoparietal region unilaterally. Biopsy of the area demonstrated progressive multifocal leukoencephalopathy positive for JC virus and p53. Treatment with interleukin-2 at 0.5 MU/m2/day i.v. continuous infusion resulted in near complete resolution of symptoms and MRI abnormalities. The absolute number of CD3+CD4+ and CD3-CD56+ cells in the peripheral blood also increased, and the CD4/CD8 ratio normalized. She remains free of evidence of progressive multifocal leukoencephalopathy 1 year off therapy.",

keywords = "Interleukin-2, JC virus, Progressive multifocal leukoencephalopathy, Treatment",

author = "D. Przepiorka and Jaeckle, {K. A.} and Birdwell, {R. R.} and Fuller, {G. N.} and Kumar, {A. J.} and Huh, {Y. O.} and I. McCutcheon",

note = "Funding Information: This work was supported in part by grant CA 16672 from the National Cancer Institute.",

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doi = "10.1038/sj.bmt.1701010",

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AU - Przepiorka, D.

AU - Jaeckle, K. A.

AU - Birdwell, R. R.

AU - Fuller, G. N.

AU - Kumar, A. J.

AU - Huh, Y. O.

AU - McCutcheon, I.

N1 - Funding Information: This work was supported in part by grant CA 16672 from the National Cancer Institute.

PY - 1997/12/1

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N2 - A patient with low-grade lymphoma presented 8 months after autologous marrow transplantation with dizziness, aphasia and hemiparesis. Magnetic resonance imaging (MRI) showed an abnormal T2 signal in the frontoparietal region unilaterally. Biopsy of the area demonstrated progressive multifocal leukoencephalopathy positive for JC virus and p53. Treatment with interleukin-2 at 0.5 MU/m2/day i.v. continuous infusion resulted in near complete resolution of symptoms and MRI abnormalities. The absolute number of CD3+CD4+ and CD3-CD56+ cells in the peripheral blood also increased, and the CD4/CD8 ratio normalized. She remains free of evidence of progressive multifocal leukoencephalopathy 1 year off therapy.

AB - A patient with low-grade lymphoma presented 8 months after autologous marrow transplantation with dizziness, aphasia and hemiparesis. Magnetic resonance imaging (MRI) showed an abnormal T2 signal in the frontoparietal region unilaterally. Biopsy of the area demonstrated progressive multifocal leukoencephalopathy positive for JC virus and p53. Treatment with interleukin-2 at 0.5 MU/m2/day i.v. continuous infusion resulted in near complete resolution of symptoms and MRI abnormalities. The absolute number of CD3+CD4+ and CD3-CD56+ cells in the peripheral blood also increased, and the CD4/CD8 ratio normalized. She remains free of evidence of progressive multifocal leukoencephalopathy 1 year off therapy.

KW - Interleukin-2

KW - JC virus

KW - Progressive multifocal leukoencephalopathy

KW - Treatment

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Successful treatment of progressive multifocal leukoencephalopathy with low-dose interleukin-2

Abstract

Keywords

ASJC Scopus subject areas

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