Subtle BBB alterations in brain edema associated with acute liver failure

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Vasogenic mechanism of brain edema in acute liver failure (ALF) remains poorly understood. Recent work demonstrates that matrix metalloproteinase-9 (MMP-9) contributes to the development of brain edema in experimental ALF (J Hepatol 44:1105, 2006). Importantly, MMP-9 blockage with specific monoclonal antibodies and/or synthetic inhibitor, the edema is attenuated. Specifically, utrastructural evaluations demonstrate intact blood-brain barrier and its tight junction. These results suggest that subtle alterations in BBB are likely to involve in the brain edema associated with ALF.

Original languageEnglish (US)
Pages (from-to)1-2
Number of pages2
JournalNeurochemistry International
Volume56
Issue number1
DOIs
StatePublished - Jan 2010

Fingerprint

Acute Liver Failure
Brain Edema
Matrix Metalloproteinase 9
Tight Junctions
Blood-Brain Barrier
Edema
Monoclonal Antibodies

Keywords

  • Acute liver failure
  • Blood-brain barrier
  • Brain edema

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Subtle BBB alterations in brain edema associated with acute liver failure. / Nguyen, Justin H.

In: Neurochemistry International, Vol. 56, No. 1, 01.2010, p. 1-2.

Research output: Contribution to journalArticle

@article{7e0e559f6eee4e27946b3886218aa4d4,
title = "Subtle BBB alterations in brain edema associated with acute liver failure",
abstract = "Vasogenic mechanism of brain edema in acute liver failure (ALF) remains poorly understood. Recent work demonstrates that matrix metalloproteinase-9 (MMP-9) contributes to the development of brain edema in experimental ALF (J Hepatol 44:1105, 2006). Importantly, MMP-9 blockage with specific monoclonal antibodies and/or synthetic inhibitor, the edema is attenuated. Specifically, utrastructural evaluations demonstrate intact blood-brain barrier and its tight junction. These results suggest that subtle alterations in BBB are likely to involve in the brain edema associated with ALF.",
keywords = "Acute liver failure, Blood-brain barrier, Brain edema",
author = "Nguyen, {Justin H}",
year = "2010",
month = "1",
doi = "10.1016/j.neuint.2010.01.008",
language = "English (US)",
volume = "56",
pages = "1--2",
journal = "Neurochemistry International",
issn = "0197-0186",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Subtle BBB alterations in brain edema associated with acute liver failure

AU - Nguyen, Justin H

PY - 2010/1

Y1 - 2010/1

N2 - Vasogenic mechanism of brain edema in acute liver failure (ALF) remains poorly understood. Recent work demonstrates that matrix metalloproteinase-9 (MMP-9) contributes to the development of brain edema in experimental ALF (J Hepatol 44:1105, 2006). Importantly, MMP-9 blockage with specific monoclonal antibodies and/or synthetic inhibitor, the edema is attenuated. Specifically, utrastructural evaluations demonstrate intact blood-brain barrier and its tight junction. These results suggest that subtle alterations in BBB are likely to involve in the brain edema associated with ALF.

AB - Vasogenic mechanism of brain edema in acute liver failure (ALF) remains poorly understood. Recent work demonstrates that matrix metalloproteinase-9 (MMP-9) contributes to the development of brain edema in experimental ALF (J Hepatol 44:1105, 2006). Importantly, MMP-9 blockage with specific monoclonal antibodies and/or synthetic inhibitor, the edema is attenuated. Specifically, utrastructural evaluations demonstrate intact blood-brain barrier and its tight junction. These results suggest that subtle alterations in BBB are likely to involve in the brain edema associated with ALF.

KW - Acute liver failure

KW - Blood-brain barrier

KW - Brain edema

UR - http://www.scopus.com/inward/record.url?scp=73449104202&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73449104202&partnerID=8YFLogxK

U2 - 10.1016/j.neuint.2010.01.008

DO - 10.1016/j.neuint.2010.01.008

M3 - Article

VL - 56

SP - 1

EP - 2

JO - Neurochemistry International

JF - Neurochemistry International

SN - 0197-0186

IS - 1

ER -