Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer's Disease

PREVENT-AD Research Group

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Both subjective cognitive decline (SCD) and a family history of Alzheimer's disease (AD) portend risk of brain abnormalities and progression to dementia. Posterior default mode network (pDMN) connectivity is altered early in the course of AD. It is unclear whether SCD predicts similar outcomes in cognitively normal individuals with a family history of AD. Methods: We studied 124 asymptomatic individuals with a family history of AD (age 64 ± 5 years). Participants were categorized as having SCD if they reported that their memory was becoming worse (SCD+). We used extensive neuropsychological assessment to investigate five different cognitive domain performances at baseline (n = 124) and 1 year later (n = 59). We assessed interconnectivity among three a priori defined ROIs: pDMN, anterior ventral DMN, medial temporal memory system (MTMS), and the connectivity of each with the rest of brain. Results: Sixty-eight (55%) participants reported SCD. Baseline cognitive performance was comparable between groups (all false discovery rate-adjusted p values >.05). At follow-up, immediate and delayed memory improved across groups, but the improvement in immediate memory was reduced in SCD+ compared with SCD (all false discovery rate–adjusted p values <.05). When compared with SCD, SCD+ subjects showed increased pDMN–MTMS connectivity (false discovery rate–adjusted p <.05). Higher connectivity between the MTMS and the rest of the brain was associated with better baseline immediate memory, attention, and global cognition, whereas higher MTMS and pDMN–MTMS connectivity were associated with lower immediate memory over time (all false discovery rate–adjusted p values <.05). Conclusions: SCD in cognitively normal individuals is associated with diminished immediate memory practice effects and a brain connectivity pattern that mirrors early AD-related connectivity failure.

Original languageEnglish (US)
Pages (from-to)463-472
Number of pages10
JournalBiological Psychiatry: Cognitive Neuroscience and Neuroimaging
Volume3
Issue number5
DOIs
StatePublished - May 1 2018

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Alzheimer Disease
Short-Term Memory
Brain
Cognitive Dysfunction
Repression (Psychology)
Cognition
Dementia

Keywords

  • Alzheimer's disease
  • Cognition
  • Default mode network connectivity
  • Family history of dementia
  • Resting-state functional MRI
  • Subjective cognitive decline

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cognitive Neuroscience
  • Clinical Neurology
  • Biological Psychiatry

Cite this

@article{821e79363837455ca822d2d23d347ddb,
title = "Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer's Disease",
abstract = "Background: Both subjective cognitive decline (SCD) and a family history of Alzheimer's disease (AD) portend risk of brain abnormalities and progression to dementia. Posterior default mode network (pDMN) connectivity is altered early in the course of AD. It is unclear whether SCD predicts similar outcomes in cognitively normal individuals with a family history of AD. Methods: We studied 124 asymptomatic individuals with a family history of AD (age 64 ± 5 years). Participants were categorized as having SCD if they reported that their memory was becoming worse (SCD+). We used extensive neuropsychological assessment to investigate five different cognitive domain performances at baseline (n = 124) and 1 year later (n = 59). We assessed interconnectivity among three a priori defined ROIs: pDMN, anterior ventral DMN, medial temporal memory system (MTMS), and the connectivity of each with the rest of brain. Results: Sixty-eight (55{\%}) participants reported SCD. Baseline cognitive performance was comparable between groups (all false discovery rate-adjusted p values >.05). At follow-up, immediate and delayed memory improved across groups, but the improvement in immediate memory was reduced in SCD+ compared with SCD− (all false discovery rate–adjusted p values <.05). When compared with SCD−, SCD+ subjects showed increased pDMN–MTMS connectivity (false discovery rate–adjusted p <.05). Higher connectivity between the MTMS and the rest of the brain was associated with better baseline immediate memory, attention, and global cognition, whereas higher MTMS and pDMN–MTMS connectivity were associated with lower immediate memory over time (all false discovery rate–adjusted p values <.05). Conclusions: SCD in cognitively normal individuals is associated with diminished immediate memory practice effects and a brain connectivity pattern that mirrors early AD-related connectivity failure.",
keywords = "Alzheimer's disease, Cognition, Default mode network connectivity, Family history of dementia, Resting-state functional MRI, Subjective cognitive decline",
author = "{PREVENT-AD Research Group} and Verfaillie, {Sander C.J.} and {Pichet Binette}, Alexa and Etienne Vachon-Presseau and Shirin Tabrizi and M{\'e}lissa Savard and Pierre Bellec and Rik Ossenkoppele and Philip Scheltens and {van der Flier}, {Wiesje M.} and Breitner, {John C.S.} and Sylvia Villeneuve and Paul Aisen and Elena Anthal and Melissa Appleby and G{\"u}lebru Ayranci and Alan Barkun and Thomas Beaudry and Pierre Bellec and Fatiha Benbouhoud and Veronique Bohbot and Jason Brandt and John Breitner and Leopoldina Carmo and {Carrier Charles}, Edouard and Mallar Chakravarty and Laksanun Cheewakriengkrai and Louis Collins and Blandine Courcot and Doris Couture and Suzanne Craft and Claudio Cuello and Mahsa Dadar and Christian Dansereau and DasSamir and Marina, {Dauar Tedeschi} and Doris Dea and Clement Debacker and Rene Desautels and Sylvie Dubuc and Guerda Duclair and Marianne Dufour and Mark Eisenberg and Rana El-Khoury and Pierre Etienne and Alan Evans and Faubert, {Anne Marie} and Fabiola Ferdinand and Vladimir Fonov and Jack, {Clifford R Jr.} and Knopman, {David S}",
year = "2018",
month = "5",
day = "1",
doi = "10.1016/j.bpsc.2017.11.012",
language = "English (US)",
volume = "3",
pages = "463--472",
journal = "Biological Psychiatry: Cognitive Neuroscience and Neuroimaging",
issn = "2451-9022",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer's Disease

AU - PREVENT-AD Research Group

AU - Verfaillie, Sander C.J.

AU - Pichet Binette, Alexa

AU - Vachon-Presseau, Etienne

AU - Tabrizi, Shirin

AU - Savard, Mélissa

AU - Bellec, Pierre

AU - Ossenkoppele, Rik

AU - Scheltens, Philip

AU - van der Flier, Wiesje M.

AU - Breitner, John C.S.

AU - Villeneuve, Sylvia

AU - Aisen, Paul

AU - Anthal, Elena

AU - Appleby, Melissa

AU - Ayranci, Gülebru

AU - Barkun, Alan

AU - Beaudry, Thomas

AU - Bellec, Pierre

AU - Benbouhoud, Fatiha

AU - Bohbot, Veronique

AU - Brandt, Jason

AU - Breitner, John

AU - Carmo, Leopoldina

AU - Carrier Charles, Edouard

AU - Chakravarty, Mallar

AU - Cheewakriengkrai, Laksanun

AU - Collins, Louis

AU - Courcot, Blandine

AU - Couture, Doris

AU - Craft, Suzanne

AU - Cuello, Claudio

AU - Dadar, Mahsa

AU - Dansereau, Christian

AU - DasSamir,

AU - Marina, Dauar Tedeschi

AU - Dea, Doris

AU - Debacker, Clement

AU - Desautels, Rene

AU - Dubuc, Sylvie

AU - Duclair, Guerda

AU - Dufour, Marianne

AU - Eisenberg, Mark

AU - El-Khoury, Rana

AU - Etienne, Pierre

AU - Evans, Alan

AU - Faubert, Anne Marie

AU - Ferdinand, Fabiola

AU - Fonov, Vladimir

AU - Jack, Clifford R Jr.

AU - Knopman, David S

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Background: Both subjective cognitive decline (SCD) and a family history of Alzheimer's disease (AD) portend risk of brain abnormalities and progression to dementia. Posterior default mode network (pDMN) connectivity is altered early in the course of AD. It is unclear whether SCD predicts similar outcomes in cognitively normal individuals with a family history of AD. Methods: We studied 124 asymptomatic individuals with a family history of AD (age 64 ± 5 years). Participants were categorized as having SCD if they reported that their memory was becoming worse (SCD+). We used extensive neuropsychological assessment to investigate five different cognitive domain performances at baseline (n = 124) and 1 year later (n = 59). We assessed interconnectivity among three a priori defined ROIs: pDMN, anterior ventral DMN, medial temporal memory system (MTMS), and the connectivity of each with the rest of brain. Results: Sixty-eight (55%) participants reported SCD. Baseline cognitive performance was comparable between groups (all false discovery rate-adjusted p values >.05). At follow-up, immediate and delayed memory improved across groups, but the improvement in immediate memory was reduced in SCD+ compared with SCD− (all false discovery rate–adjusted p values <.05). When compared with SCD−, SCD+ subjects showed increased pDMN–MTMS connectivity (false discovery rate–adjusted p <.05). Higher connectivity between the MTMS and the rest of the brain was associated with better baseline immediate memory, attention, and global cognition, whereas higher MTMS and pDMN–MTMS connectivity were associated with lower immediate memory over time (all false discovery rate–adjusted p values <.05). Conclusions: SCD in cognitively normal individuals is associated with diminished immediate memory practice effects and a brain connectivity pattern that mirrors early AD-related connectivity failure.

AB - Background: Both subjective cognitive decline (SCD) and a family history of Alzheimer's disease (AD) portend risk of brain abnormalities and progression to dementia. Posterior default mode network (pDMN) connectivity is altered early in the course of AD. It is unclear whether SCD predicts similar outcomes in cognitively normal individuals with a family history of AD. Methods: We studied 124 asymptomatic individuals with a family history of AD (age 64 ± 5 years). Participants were categorized as having SCD if they reported that their memory was becoming worse (SCD+). We used extensive neuropsychological assessment to investigate five different cognitive domain performances at baseline (n = 124) and 1 year later (n = 59). We assessed interconnectivity among three a priori defined ROIs: pDMN, anterior ventral DMN, medial temporal memory system (MTMS), and the connectivity of each with the rest of brain. Results: Sixty-eight (55%) participants reported SCD. Baseline cognitive performance was comparable between groups (all false discovery rate-adjusted p values >.05). At follow-up, immediate and delayed memory improved across groups, but the improvement in immediate memory was reduced in SCD+ compared with SCD− (all false discovery rate–adjusted p values <.05). When compared with SCD−, SCD+ subjects showed increased pDMN–MTMS connectivity (false discovery rate–adjusted p <.05). Higher connectivity between the MTMS and the rest of the brain was associated with better baseline immediate memory, attention, and global cognition, whereas higher MTMS and pDMN–MTMS connectivity were associated with lower immediate memory over time (all false discovery rate–adjusted p values <.05). Conclusions: SCD in cognitively normal individuals is associated with diminished immediate memory practice effects and a brain connectivity pattern that mirrors early AD-related connectivity failure.

KW - Alzheimer's disease

KW - Cognition

KW - Default mode network connectivity

KW - Family history of dementia

KW - Resting-state functional MRI

KW - Subjective cognitive decline

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U2 - 10.1016/j.bpsc.2017.11.012

DO - 10.1016/j.bpsc.2017.11.012

M3 - Article

C2 - 29735156

AN - SCOPUS:85041617475

VL - 3

SP - 463

EP - 472

JO - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

SN - 2451-9022

IS - 5

ER -