Study of mitochondrial DNA mutations in patients with migraine with prolonged aura

Todd D. Rozen; Sara Shanske; David Otaegui; Jiesheng Lu; William B. Young; Kathy Bradley; Salvatore DiMauro; Stephen D. Silberstein

doi:10.1111/j.1526-4610.2004.04126.x

Study of mitochondrial DNA mutations in patients with migraine with prolonged aura

Todd D. Rozen, Sara Shanske, David Otaegui, Jiesheng Lu, William B. Young, Kathy Bradley, Salvatore DiMauro, Stephen D. Silberstein

Neurology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Ten patients with migraine with prolonged aura were studied for the presence of mitochondrial DNA point mutations utilizing DNA isolated from blood and hair samples. We analyzed for nine point mutations reported in patients with MELAS (A3243G, C3256T, T3271C, T3291C, A5814G, T8356C, T9957C, G13513A, and A13514G) and three secondary LHON mutations (T4216C, A4917G, and G13708A). None of the patients tested had any of these mutations in mitochondrial DNA. However, one patient was found to have a tRNA(Gln) A4336G mitochondrial DNA variant. From this study it appears that migraine with prolonged aura is not an oligosymptomatic form of MELAS and is not related to secondary LHON mutations. The significance of the tRNA A4336G variant is unknown.

Original language	English (US)
Pages (from-to)	674-677
Number of pages	4
Journal	Headache
Volume	44
Issue number	7
DOIs	https://doi.org/10.1111/j.1526-4610.2004.04126.x
State	Published - Jul 2004

Keywords

DNA
Migraine
Mitochondria
Mitochondrial
Prolonged aura

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1111/j.1526-4610.2004.04126.x

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title = "Study of mitochondrial DNA mutations in patients with migraine with prolonged aura",

abstract = "Ten patients with migraine with prolonged aura were studied for the presence of mitochondrial DNA point mutations utilizing DNA isolated from blood and hair samples. We analyzed for nine point mutations reported in patients with MELAS (A3243G, C3256T, T3271C, T3291C, A5814G, T8356C, T9957C, G13513A, and A13514G) and three secondary LHON mutations (T4216C, A4917G, and G13708A). None of the patients tested had any of these mutations in mitochondrial DNA. However, one patient was found to have a tRNA(Gln) A4336G mitochondrial DNA variant. From this study it appears that migraine with prolonged aura is not an oligosymptomatic form of MELAS and is not related to secondary LHON mutations. The significance of the tRNA A4336G variant is unknown.",

keywords = "DNA, Migraine, Mitochondria, Mitochondrial, Prolonged aura",

author = "Rozen, {Todd D.} and Sara Shanske and David Otaegui and Jiesheng Lu and Young, {William B.} and Kathy Bradley and Salvatore DiMauro and Silberstein, {Stephen D.}",

year = "2004",

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doi = "10.1111/j.1526-4610.2004.04126.x",

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journal = "Headache",

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AU - Rozen, Todd D.

AU - Shanske, Sara

AU - Otaegui, David

AU - Lu, Jiesheng

AU - Young, William B.

AU - Bradley, Kathy

AU - DiMauro, Salvatore

AU - Silberstein, Stephen D.

PY - 2004/7

Y1 - 2004/7

N2 - Ten patients with migraine with prolonged aura were studied for the presence of mitochondrial DNA point mutations utilizing DNA isolated from blood and hair samples. We analyzed for nine point mutations reported in patients with MELAS (A3243G, C3256T, T3271C, T3291C, A5814G, T8356C, T9957C, G13513A, and A13514G) and three secondary LHON mutations (T4216C, A4917G, and G13708A). None of the patients tested had any of these mutations in mitochondrial DNA. However, one patient was found to have a tRNA(Gln) A4336G mitochondrial DNA variant. From this study it appears that migraine with prolonged aura is not an oligosymptomatic form of MELAS and is not related to secondary LHON mutations. The significance of the tRNA A4336G variant is unknown.

AB - Ten patients with migraine with prolonged aura were studied for the presence of mitochondrial DNA point mutations utilizing DNA isolated from blood and hair samples. We analyzed for nine point mutations reported in patients with MELAS (A3243G, C3256T, T3271C, T3291C, A5814G, T8356C, T9957C, G13513A, and A13514G) and three secondary LHON mutations (T4216C, A4917G, and G13708A). None of the patients tested had any of these mutations in mitochondrial DNA. However, one patient was found to have a tRNA(Gln) A4336G mitochondrial DNA variant. From this study it appears that migraine with prolonged aura is not an oligosymptomatic form of MELAS and is not related to secondary LHON mutations. The significance of the tRNA A4336G variant is unknown.

KW - DNA

KW - Migraine

KW - Mitochondria

KW - Mitochondrial

KW - Prolonged aura

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JF - Headache

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ER -

Study of mitochondrial DNA mutations in patients with migraine with prolonged aura

Abstract

Keywords

ASJC Scopus subject areas

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