Study of mitochondrial DNA mutations in patients with migraine with prolonged aura

Todd D. Rozen, Sara Shanske, David Otaegui, Jiesheng Lu, William B. Young, Kathy Bradley, Salvatore DiMauro, Stephen D. Silberstein

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Ten patients with migraine with prolonged aura were studied for the presence of mitochondrial DNA point mutations utilizing DNA isolated from blood and hair samples. We analyzed for nine point mutations reported in patients with MELAS (A3243G, C3256T, T3271C, T3291C, A5814G, T8356C, T9957C, G13513A, and A13514G) and three secondary LHON mutations (T4216C, A4917G, and G13708A). None of the patients tested had any of these mutations in mitochondrial DNA. However, one patient was found to have a tRNA(Gln) A4336G mitochondrial DNA variant. From this study it appears that migraine with prolonged aura is not an oligosymptomatic form of MELAS and is not related to secondary LHON mutations. The significance of the tRNA A4336G variant is unknown.

Original languageEnglish (US)
Pages (from-to)674-677
Number of pages4
JournalHeadache
Volume44
Issue number7
DOIs
StatePublished - Jul 1 2004

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Keywords

  • DNA
  • Migraine
  • Mitochondria
  • Mitochondrial
  • Prolonged aura

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Rozen, T. D., Shanske, S., Otaegui, D., Lu, J., Young, W. B., Bradley, K., DiMauro, S., & Silberstein, S. D. (2004). Study of mitochondrial DNA mutations in patients with migraine with prolonged aura. Headache, 44(7), 674-677. https://doi.org/10.1111/j.1526-4610.2004.04126.x