Studies to improve fixation of human nerves. IV: Effect of time elapsed between death and glutaraldehyde fixation on density of microtubules and neurofilaments

Akio Ohnishi, Peter C. O’Brien, Peter James Dyck

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Glutaraldehyde fixation of rat peroneal nerves after the animal was killed (simulated autopsy) was associated with a statistically significant decrease of density (number per unit area) of microtubules (MT) in comparison with controls (simulated biopsy). The density of MT decreased progressively with prolongation of time elapsed prior to glutaraldehyde fixation (1, G, and 12 hours). Such a time effect was not demonstrated for density of neurofilaments.

Original languageEnglish (US)
Pages (from-to)26-29
Number of pages4
JournalJournal of Neuropathology and Experimental Neurology
Volume35
Issue number1
DOIs
StatePublished - Jan 1 1976

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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