TY - JOUR
T1 - Studies to improve fixation of human nerves. IV
T2 - Effect of time elapsed between death and glutaraldehyde fixation on density of microtubules and neurofilaments
AU - Ohnishi, Akio
AU - O’Brien, Peter C.
AU - Dyck, Peter James
PY - 1976
Y1 - 1976
N2 - Glutaraldehyde fixation of rat peroneal nerves after the animal was killed (simulated autopsy) was associated with a statistically significant decrease of density (number per unit area) of microtubules (MT) in comparison with controls (simulated biopsy). The density of MT decreased progressively with prolongation of time elapsed prior to glutaraldehyde fixation (1, G, and 12 hours). Such a time effect was not demonstrated for density of neurofilaments.
AB - Glutaraldehyde fixation of rat peroneal nerves after the animal was killed (simulated autopsy) was associated with a statistically significant decrease of density (number per unit area) of microtubules (MT) in comparison with controls (simulated biopsy). The density of MT decreased progressively with prolongation of time elapsed prior to glutaraldehyde fixation (1, G, and 12 hours). Such a time effect was not demonstrated for density of neurofilaments.
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U2 - 10.1097/00005072-197601000-00003
DO - 10.1097/00005072-197601000-00003
M3 - Article
C2 - 812962
AN - SCOPUS:0017105240
SN - 0022-3069
VL - 35
SP - 26
EP - 29
JO - Journal of neuropathology and experimental neurology
JF - Journal of neuropathology and experimental neurology
IS - 1
ER -