Studies to improve fixation of human nerves. IV. Effect of time elapsed between death and glutaraldehyde fixation on density of microtubules and neurofilaments

A. Ohnishi, P. C. O'Brien, Peter J Dyck

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Abstract

Glutaraldehyde fixation of rat peroneal nerves after killing the animal (simulated autopsy) was associated with a statistically significant decrease of density (number per unit area) of microtubules (MT) in comparison with controls (simulated biopsy). The density of MT decreased progressively with prolongation of time elapsed prior to glutaraldehyde fixation (1, 6, and 12 hr). Such a time effect was not demonstrated for density of neurofilaments.

Original languageEnglish (US)
Pages (from-to)26-29
Number of pages4
JournalJournal of Neuropathology and Experimental Neurology
Volume35
Issue number1
StatePublished - 1976

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

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