Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis

Medicine & Life Sciences

• human LIG4 protein 100%
• Catalysis 55%
• Ligases 50%
• Catalytic Domain 41%
• DNA Ligase ATP 36%
• Single-Stranded DNA Breaks 31%
• LIG4 Syndrome 24%
• Immunoglobulin Genes 14%
• Radiation Tolerance 13%
• Double-Stranded DNA Breaks 13%
• Mutation 12%
• Adenosine Monophosphate 12%
• Mutagenesis 11%
• Nucleic Acids 11%
• DNA 6%

Physics & Astronomy

• catalysis 53%
• deoxyribonucleic acid 42%
• sealing 18%
• mutations 17%
• adenosine monophosphate 12%
• mutagenesis 11%
• nucleic acids 10%
• genes 9%
• strands 8%
• crystal structure 6%
• causes 4%
• radiation 4%
• interactions 3%

Chemical Compounds

• Mutation 39%
• Catalysis 29%
• Genotoxic 27%
• Nucleic Acid 19%
• Crystal Structure 11%