Structure and function of the cell surface (tethered) mucins

Christine L. Hattrup, Sandra J Gendler

Research output: Contribution to journalArticle

406 Citations (Scopus)

Abstract

Cell surface mucins are large transmembrane glycoproteins involved in diverse functions ranging from shielding the airway epithelium against pathogenic infection to regulating cellular signaling and transcription. Although hampered by the relatively recent characterization of cell surface mucins and the difficulties inherent in working with molecules of their size, numerous studies have placed the tethered mucins in the thick of normal and diseased lung physiology. This review focuses on the three best-characterized cell surface mucins expressed in the respiratory tract: MUC1, MUC4, and MUC16.

Original languageEnglish (US)
Pages (from-to)431-457
Number of pages27
JournalAnnual Review of Physiology
Volume70
DOIs
StatePublished - 2008

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Mucins
Respiratory System
Lung Diseases
Glycoproteins
Epithelium
Infection

Keywords

  • Cancer
  • MUC1
  • MUC16
  • MUC4
  • Respiratory disease
  • Signaling

ASJC Scopus subject areas

  • Physiology

Cite this

Structure and function of the cell surface (tethered) mucins. / Hattrup, Christine L.; Gendler, Sandra J.

In: Annual Review of Physiology, Vol. 70, 2008, p. 431-457.

Research output: Contribution to journalArticle

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