Structural Imaging of Mild Cognitive Impairment

This chapter describes the concept of mild cognitive impairment (MCI), the initial construct of amnestic MCI as well as the expanded construct that includes both amnestic and nonamnestic forms. The focus of the chapter is on quantitative magnetic resonance (MR) imaging studies in MCI. While the major emphasis is on structural MRI, other MR imaging techniques such as spectroscopy and diffusion imaging are described in the context of MCI. Specifically, relationships between imaging and clinical features of MCI in cross-sectional and longitudinal contexts are outlined. The chapter also describes the complementary nature of the information provided by MRI and amyloid imaging.