Stroke Genetics Update: 2011

John W. Cole, James F. Meschia

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Although stroke remains a leading cause of disability and mortality worldwide, recently there have been significant advances related to our understanding of the genetic basis of stroke. Ongoing research efforts put us on the cusp for major breakthroughs in the field. In this review, we present the substantial evidence for the contribution of genetic variation to the development of stroke, and the difficulties posed in the study of stroke given the numerous genetically driven risk factors and stroke subtypes. We emphasize recent findings implementing candidate gene and genome-wide association approaches. We then discuss how emerging knowledge is informing and reshaping our understanding of stroke biology and how, in the near term, genetics may be used clinically to identify individuals who are at risk of disease or who may derive benefit from specific treatment modalities. Lastly, we address ongoing and future approaches that will continue to improve our understanding of stroke genetics.

Original languageEnglish (US)
Pages (from-to)533-541
Number of pages9
JournalCurrent Cardiovascular Risk Reports
Volume5
Issue number6
DOIs
StatePublished - 2011

Keywords

  • Genetics
  • Genome-wide association studies
  • Stroke

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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