Streptozotocin, 1982-2022: Forty Years from the FDA's Approval to Treat Pancreatic Neuroendocrine Tumors

Jaume Capdevila; Michel Ducreux; Rocio García Carbonero; Enrique Grande; Thorvardur Halfdanarson; Marianne Pavel; Salvatore Tafuto; Staffan Welin; Vicente Valentí; Ramón Salazar

doi:10.1159/000524988

Streptozotocin, 1982-2022: Forty Years from the FDA's Approval to Treat Pancreatic Neuroendocrine Tumors

Jaume Capdevila, Michel Ducreux, Rocio García Carbonero, Enrique Grande, Thorvardur Halfdanarson, Marianne Pavel, Salvatore Tafuto, Staffan Welin, Vicente Valentí, Ramón Salazar

Medical Oncology

Research output: Contribution to journal › Article › peer-review

Abstract

In May 1982, the US Food and Drug Administration (FDA) approved the use of streptozotocin to treat pancreatic neuroendocrine tumors (panNETs). Thus, this year marks 40 years since that landmark date. This review of streptozotocin to treat panNETs is intended to commemorate this anniversary. A historical perspective of the chemical structure, pharmacokinetics, and mechanism of action of streptozotocin is followed by data from prospective and retrospective clinical studies. The last section of the review addresses the latest aspects and takes note of the prospects that lie ahead on the future horizon of the use of streptozotocin to treat panNETs, including ongoing clinical trials.

Original language	English (US)
Pages (from-to)	1155-1167
Number of pages	13
Journal	Neuroendocrinology
Volume	112
Issue number	12
DOIs	https://doi.org/10.1159/000524988
State	Published - Nov 1 2022

Keywords

Historical review
Pancreatic neuroendocrine tumors
Streptozotocin

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

Access to Document

10.1159/000524988

Cite this

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abstract = "In May 1982, the US Food and Drug Administration (FDA) approved the use of streptozotocin to treat pancreatic neuroendocrine tumors (panNETs). Thus, this year marks 40 years since that landmark date. This review of streptozotocin to treat panNETs is intended to commemorate this anniversary. A historical perspective of the chemical structure, pharmacokinetics, and mechanism of action of streptozotocin is followed by data from prospective and retrospective clinical studies. The last section of the review addresses the latest aspects and takes note of the prospects that lie ahead on the future horizon of the use of streptozotocin to treat panNETs, including ongoing clinical trials.",

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AU - Grande, Enrique

AU - Halfdanarson, Thorvardur

AU - Pavel, Marianne

AU - Tafuto, Salvatore

AU - Welin, Staffan

AU - Valentí, Vicente

AU - Salazar, Ramón

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AB - In May 1982, the US Food and Drug Administration (FDA) approved the use of streptozotocin to treat pancreatic neuroendocrine tumors (panNETs). Thus, this year marks 40 years since that landmark date. This review of streptozotocin to treat panNETs is intended to commemorate this anniversary. A historical perspective of the chemical structure, pharmacokinetics, and mechanism of action of streptozotocin is followed by data from prospective and retrospective clinical studies. The last section of the review addresses the latest aspects and takes note of the prospects that lie ahead on the future horizon of the use of streptozotocin to treat panNETs, including ongoing clinical trials.

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Streptozotocin, 1982-2022: Forty Years from the FDA's Approval to Treat Pancreatic Neuroendocrine Tumors

Abstract

Keywords

ASJC Scopus subject areas

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