Strategies to increase responsiveness to hepatitis B vaccination in adults with HIV-1

Jennifer A. Whitaker, Nadine G. Rouphael, Srilatha Edupuganti, Lilin Lai, Mark J. Mulligan

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

HIV and hepatitis B virus co-infection leads to substantially increased morbidity and mortality compared with either infection alone. Immunisation with hepatitis B virus vaccine is the most effective way to prevent the infection in people with HIV; however, these patients have decreased vaccine responses and a short duration of protection compared with immunocompetent individuals. Control of HIV replication with highly active antiretroviral therapy and increased CD4 cell counts are associated with improved immune responses to hepatitis B vaccination. New vaccination strategies, such as increased vaccine dose, use of the intradermal route, and addition of adjuvants, could improve response rates in adults with HIV.

Original languageEnglish (US)
Pages (from-to)966-976
Number of pages11
JournalThe Lancet Infectious Diseases
Volume12
Issue number12
DOIs
StatePublished - Dec 2012

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Hepatitis B
HIV-1
Vaccination
HIV
Hepatitis B virus
Vaccines
Hepatitis B Vaccines
Highly Active Antiretroviral Therapy
Virus Diseases
CD4 Lymphocyte Count
Infection
Coinfection
Immunization
Morbidity
Mortality

ASJC Scopus subject areas

  • Medicine(all)
  • Infectious Diseases

Cite this

Strategies to increase responsiveness to hepatitis B vaccination in adults with HIV-1. / Whitaker, Jennifer A.; Rouphael, Nadine G.; Edupuganti, Srilatha; Lai, Lilin; Mulligan, Mark J.

In: The Lancet Infectious Diseases, Vol. 12, No. 12, 12.2012, p. 966-976.

Research output: Contribution to journalReview article

Whitaker, JA, Rouphael, NG, Edupuganti, S, Lai, L & Mulligan, MJ 2012, 'Strategies to increase responsiveness to hepatitis B vaccination in adults with HIV-1', The Lancet Infectious Diseases, vol. 12, no. 12, pp. 966-976. https://doi.org/10.1016/S1473-3099(12)70243-8
Whitaker, Jennifer A. ; Rouphael, Nadine G. ; Edupuganti, Srilatha ; Lai, Lilin ; Mulligan, Mark J. / Strategies to increase responsiveness to hepatitis B vaccination in adults with HIV-1. In: The Lancet Infectious Diseases. 2012 ; Vol. 12, No. 12. pp. 966-976.
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