Strategies to increase responsiveness to hepatitis B vaccination in adults with HIV-1

Jennifer A. Whitaker, Nadine G. Rouphael, Srilatha Edupuganti, Lilin Lai, Mark J. Mulligan

Research output: Contribution to journalReview article

37 Scopus citations


HIV and hepatitis B virus co-infection leads to substantially increased morbidity and mortality compared with either infection alone. Immunisation with hepatitis B virus vaccine is the most effective way to prevent the infection in people with HIV; however, these patients have decreased vaccine responses and a short duration of protection compared with immunocompetent individuals. Control of HIV replication with highly active antiretroviral therapy and increased CD4 cell counts are associated with improved immune responses to hepatitis B vaccination. New vaccination strategies, such as increased vaccine dose, use of the intradermal route, and addition of adjuvants, could improve response rates in adults with HIV.

Original languageEnglish (US)
Pages (from-to)966-976
Number of pages11
JournalThe Lancet Infectious Diseases
Issue number12
StatePublished - Dec 1 2012


ASJC Scopus subject areas

  • Infectious Diseases

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