Strategies targeting cAMP signaling in the treatment of polycystic kidney disease

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Polycystic kidney disease (PKD) is a leading cause of ESRD worldwide. In PKD, excessive cell proliferation and fluid secretion, pathogenic interactions of mutated epithelial cells with an abnormal extracellular matrix and alternatively activated interstitial macrophages, and the disruption of mechanisms controlling tubular diameter contribute to cyst formation. Studies with animal models suggest that several diverse pathophysiologic mechanisms, including dysregulation of intracellular calcium levels and cAMP signaling,mediate these cystogenicmechanisms. This article reviews the evidence implicating calcium and cAMP as central players in a network of signaling pathways underlying the pathogenesis of PKD and considers the therapeutic relevance of treatment strategies targeting cAMP signaling.

Original languageEnglish (US)
Pages (from-to)18-32
Number of pages15
JournalJournal of the American Society of Nephrology
Volume25
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Polycystic Kidney Diseases
Calcium
Fluids and Secretions
Chronic Kidney Failure
Extracellular Matrix
Cysts
Animal Models
Epithelial Cells
Macrophages
Cell Proliferation
Therapeutics

ASJC Scopus subject areas

  • Nephrology

Cite this

@article{9ba0ba8f0fc14962b69d7368e7cf1622,
title = "Strategies targeting cAMP signaling in the treatment of polycystic kidney disease",
abstract = "Polycystic kidney disease (PKD) is a leading cause of ESRD worldwide. In PKD, excessive cell proliferation and fluid secretion, pathogenic interactions of mutated epithelial cells with an abnormal extracellular matrix and alternatively activated interstitial macrophages, and the disruption of mechanisms controlling tubular diameter contribute to cyst formation. Studies with animal models suggest that several diverse pathophysiologic mechanisms, including dysregulation of intracellular calcium levels and cAMP signaling,mediate these cystogenicmechanisms. This article reviews the evidence implicating calcium and cAMP as central players in a network of signaling pathways underlying the pathogenesis of PKD and considers the therapeutic relevance of treatment strategies targeting cAMP signaling.",
author = "Vicente Torres and Harris, {Peter C}",
year = "2014",
month = "1",
doi = "10.1681/ASN.2013040398",
language = "English (US)",
volume = "25",
pages = "18--32",
journal = "Journal of the American Society of Nephrology : JASN",
issn = "1046-6673",
publisher = "American Society of Nephrology",
number = "1",

}

TY - JOUR

T1 - Strategies targeting cAMP signaling in the treatment of polycystic kidney disease

AU - Torres, Vicente

AU - Harris, Peter C

PY - 2014/1

Y1 - 2014/1

N2 - Polycystic kidney disease (PKD) is a leading cause of ESRD worldwide. In PKD, excessive cell proliferation and fluid secretion, pathogenic interactions of mutated epithelial cells with an abnormal extracellular matrix and alternatively activated interstitial macrophages, and the disruption of mechanisms controlling tubular diameter contribute to cyst formation. Studies with animal models suggest that several diverse pathophysiologic mechanisms, including dysregulation of intracellular calcium levels and cAMP signaling,mediate these cystogenicmechanisms. This article reviews the evidence implicating calcium and cAMP as central players in a network of signaling pathways underlying the pathogenesis of PKD and considers the therapeutic relevance of treatment strategies targeting cAMP signaling.

AB - Polycystic kidney disease (PKD) is a leading cause of ESRD worldwide. In PKD, excessive cell proliferation and fluid secretion, pathogenic interactions of mutated epithelial cells with an abnormal extracellular matrix and alternatively activated interstitial macrophages, and the disruption of mechanisms controlling tubular diameter contribute to cyst formation. Studies with animal models suggest that several diverse pathophysiologic mechanisms, including dysregulation of intracellular calcium levels and cAMP signaling,mediate these cystogenicmechanisms. This article reviews the evidence implicating calcium and cAMP as central players in a network of signaling pathways underlying the pathogenesis of PKD and considers the therapeutic relevance of treatment strategies targeting cAMP signaling.

UR - http://www.scopus.com/inward/record.url?scp=84891818486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891818486&partnerID=8YFLogxK

U2 - 10.1681/ASN.2013040398

DO - 10.1681/ASN.2013040398

M3 - Article

AN - SCOPUS:84891818486

VL - 25

SP - 18

EP - 32

JO - Journal of the American Society of Nephrology : JASN

JF - Journal of the American Society of Nephrology : JASN

SN - 1046-6673

IS - 1

ER -