Sterols in asthma

Mireia Guerau-de-Arellano; Rodney D. Britt

doi:10.1016/j.it.2022.08.003

Sterols in asthma

Mireia Guerau-de-Arellano, Rodney D. Britt

Physiology & Biomedical Engineering

Research output: Contribution to journal › Review article › peer-review

Abstract

While sterols regulate immune processes key to the pathogenesis of asthma, inhibition of sterols with statin drugs has shown conflicting results in human asthma. Here, a novel understanding of the impact of sterols on type 17 immune responses and asthma lead us to hypothesize that sterols and statins may be relevant to severe asthma endotypes with neutrophil infiltration.

Original language	English (US)
Journal	Trends in Immunology
DOIs	https://doi.org/10.1016/j.it.2022.08.003
State	Published - Oct 2022

Keywords

Th17
asthma
neutrophilic
severe
statin
sterol

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.it.2022.08.003

Cite this

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title = "Sterols in asthma",

abstract = "While sterols regulate immune processes key to the pathogenesis of asthma, inhibition of sterols with statin drugs has shown conflicting results in human asthma. Here, a novel understanding of the impact of sterols on type 17 immune responses and asthma lead us to hypothesize that sterols and statins may be relevant to severe asthma endotypes with neutrophil infiltration.",

keywords = "Th17, asthma, neutrophilic, severe, statin, sterol",

author = "Mireia Guerau-de-Arellano and Britt, {Rodney D.}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = oct,

doi = "10.1016/j.it.2022.08.003",

language = "English (US)",

journal = "Trends in Immunology",

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AU - Guerau-de-Arellano, Mireia

AU - Britt, Rodney D.

PY - 2022/10

Y1 - 2022/10

N2 - While sterols regulate immune processes key to the pathogenesis of asthma, inhibition of sterols with statin drugs has shown conflicting results in human asthma. Here, a novel understanding of the impact of sterols on type 17 immune responses and asthma lead us to hypothesize that sterols and statins may be relevant to severe asthma endotypes with neutrophil infiltration.

AB - While sterols regulate immune processes key to the pathogenesis of asthma, inhibition of sterols with statin drugs has shown conflicting results in human asthma. Here, a novel understanding of the impact of sterols on type 17 immune responses and asthma lead us to hypothesize that sterols and statins may be relevant to severe asthma endotypes with neutrophil infiltration.

KW - Th17

KW - asthma

KW - neutrophilic

KW - severe

KW - statin

KW - sterol

UR - http://www.scopus.com/inward/record.url?scp=85136724460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85136724460&partnerID=8YFLogxK

U2 - 10.1016/j.it.2022.08.003

DO - 10.1016/j.it.2022.08.003

M3 - Review article

C2 - 36041950

AN - SCOPUS:85136724460

SN - 1471-4906

JO - Trends in Immunology

JF - Trends in Immunology

ER -

Sterols in asthma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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