@article{04ed240e3ccd4b3389ef5ab28b2635be,
title = "Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity",
abstract = "Zhou et al. show that monounsaturated fatty acids (MUFAs), generated by stearoyl-CoA desaturase (SCD), support B cell mitochondrial metabolism and mTOR activity and promote B cell development and humoral immune responses. These data establish MUFA availability as a key regulator for humoral immunity and a potential therapeutic target.",
keywords = "B cell, autophagy, humoral immunity, mTOR, monounsaturated fatty acid, stearoyl-CoA desaturase",
author = "Xian Zhou and Xingxing Zhu and Chaofan Li and Yanfeng Li and Zhenqing Ye and Shapiro, {Virginia Smith} and Copland, {John A.} and Taro Hitosugi and Bernlohr, {David A.} and Jie Sun and Hu Zeng",
note = "Funding Information: We thank Dr. Douglas Green at St. Jude Children{\textquoteright}s Research Hospital for spleen cells from GFP-LC3 mice. We thank Dr. Michael Jensen for his expert advice on FA metabolism. This work was partly supported by National Institutes of Health (NIH) grants R01 CA225680 (to T.H.), R01 AG047156 , R01 AI112844 , and R01 AI147394 (to J.S.) and a Discovery Science Award ( 93059065 ) from the Center for Biomedical Discovery at Mayo Clinic (to H.Z.). The Mayo Clinic Metabolomics Core is supported by NIH grant U24DK100469 . Funding Information: We thank Dr. Douglas Green at St. Jude Children's Research Hospital for spleen cells from GFP-LC3 mice. We thank Dr. Michael Jensen for his expert advice on FA metabolism. This work was partly supported by National Institutes of Health (NIH) grants R01 CA225680 (to T.H.), R01 AG047156, R01 AI112844, and R01 AI147394 (to J.S.) and a Discovery Science Award (93059065) from the Center for Biomedical Discovery at Mayo Clinic (to H.Z.). The Mayo Clinic Metabolomics Core is supported by NIH grant U24DK100469. X. Zhou designed and performed the cellular, molecular, and animal experiments and wrote the manuscript. X. Zhu and Y.L. carried out animal experiments and microscopy data analysis. C.L. performed influenza infection and heatmap graph. Z.Y. performed RNA-seq data analysis. T.H. performed OA oxidation assays. J.A.C. provided SSI-4 and SSI-4 chow. V.S.S. T.H. D.A.B. and J.S. provided research materials and assisted data interpretation. H.Z. designed experiments, wrote the manuscript, and supervised the study. H.Z. and J.A.C. have a pending patent application regarding use of the SCD inhibitor SSI-4. Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2021",
month = jan,
day = "5",
doi = "10.1016/j.celrep.2020.108601",
language = "English (US)",
volume = "34",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "1",
}