Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

Xian Zhou, Xingxing Zhu, Chaofan Li, Yanfeng Li, Zhenqing Ye, Virginia Smith Shapiro, John A. Copland, Taro Hitosugi, David A. Bernlohr, Jie Sun, Hu Zeng

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Zhou et al. show that monounsaturated fatty acids (MUFAs), generated by stearoyl-CoA desaturase (SCD), support B cell mitochondrial metabolism and mTOR activity and promote B cell development and humoral immune responses. These data establish MUFA availability as a key regulator for humoral immunity and a potential therapeutic target.

Original languageEnglish (US)
Article number108601
JournalCell reports
Volume34
Issue number1
DOIs
StatePublished - Jan 5 2021

Keywords

  • B cell
  • autophagy
  • humoral immunity
  • mTOR
  • monounsaturated fatty acid
  • stearoyl-CoA desaturase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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