Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

Xian Zhou; Xingxing Zhu; Chaofan Li; Yanfeng Li; Zhenqing Ye; Virginia Smith Shapiro; John A. Copland; Taro Hitosugi; David A. Bernlohr; Jie Sun; Hu Zeng

doi:10.1016/j.celrep.2020.108601

Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

Xian Zhou, Xingxing Zhu, Chaofan Li, Yanfeng Li, Zhenqing Ye, Virginia Smith Shapiro, John A. Copland, Taro Hitosugi, David A. Bernlohr, Jie Sun, Hu Zeng

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Zhou et al. show that monounsaturated fatty acids (MUFAs), generated by stearoyl-CoA desaturase (SCD), support B cell mitochondrial metabolism and mTOR activity and promote B cell development and humoral immune responses. These data establish MUFA availability as a key regulator for humoral immunity and a potential therapeutic target.

Original language	English (US)
Article number	108601
Journal	Cell reports
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2020.108601
State	Published - Jan 5 2021

Keywords

B cell
autophagy
humoral immunity
mTOR
monounsaturated fatty acid
stearoyl-CoA desaturase

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2020.108601

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title = "Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity",

abstract = "Zhou et al. show that monounsaturated fatty acids (MUFAs), generated by stearoyl-CoA desaturase (SCD), support B cell mitochondrial metabolism and mTOR activity and promote B cell development and humoral immune responses. These data establish MUFA availability as a key regulator for humoral immunity and a potential therapeutic target.",

keywords = "B cell, autophagy, humoral immunity, mTOR, monounsaturated fatty acid, stearoyl-CoA desaturase",

author = "Xian Zhou and Xingxing Zhu and Chaofan Li and Yanfeng Li and Zhenqing Ye and Shapiro, {Virginia Smith} and Copland, {John A.} and Taro Hitosugi and Bernlohr, {David A.} and Jie Sun and Hu Zeng",

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T1 - Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

AU - Zhou, Xian

AU - Zhu, Xingxing

AU - Li, Chaofan

AU - Li, Yanfeng

AU - Ye, Zhenqing

AU - Shapiro, Virginia Smith

AU - Copland, John A.

AU - Hitosugi, Taro

AU - Bernlohr, David A.

AU - Sun, Jie

AU - Zeng, Hu

PY - 2021/1/5

Y1 - 2021/1/5

N2 - Zhou et al. show that monounsaturated fatty acids (MUFAs), generated by stearoyl-CoA desaturase (SCD), support B cell mitochondrial metabolism and mTOR activity and promote B cell development and humoral immune responses. These data establish MUFA availability as a key regulator for humoral immunity and a potential therapeutic target.

AB - Zhou et al. show that monounsaturated fatty acids (MUFAs), generated by stearoyl-CoA desaturase (SCD), support B cell mitochondrial metabolism and mTOR activity and promote B cell development and humoral immune responses. These data establish MUFA availability as a key regulator for humoral immunity and a potential therapeutic target.

KW - B cell

KW - autophagy

KW - humoral immunity

KW - mTOR

KW - monounsaturated fatty acid

KW - stearoyl-CoA desaturase

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ER -

Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

Abstract

Keywords

ASJC Scopus subject areas

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