Status of lipids, lipid peroxidation, and antioxidant systems with vitamin C supplementation during aging in rats

M. Jayachandran; B. Jayanthi; B. Sundaravadivel; C. Panneerselvam

doi:10.1016/0955-2863(96)00027-7

Status of lipids, lipid peroxidation, and antioxidant systems with vitamin C supplementation during aging in rats

M. Jayachandran, B. Jayanthi, B. Sundaravadivel, C. Panneerselvam

Cardiovascular Surgery

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22 Scopus citations

Abstract

Molecular mechanisms responsible for age-dependent deterioration of biochemical functions remain unclear. We determined the effect of ascorbic acid supplementation (20 mg/100 g body weight/day) in young and aged rats for 15, 30, and 60 days. In the aged animals cholesterol, triglycerides, phospholipids, and lipid peroxidation were considerably high, whereas, antioxidants superoxide dismutase, catalase, glutathione peroxidase, glutathione, ascorbic acid, and α-tocopherol were low. Administration of ascorbic acid reverted these age-associated differences to the status comparable to young rats.

Original language	English (US)
Pages (from-to)	270-275
Number of pages	6
Journal	Journal of Nutritional Biochemistry
Volume	7
Issue number	5
DOIs	https://doi.org/10.1016/0955-2863(96)00027-7
State	Published - May 1996

Keywords

aging
antioxidants
ascorbic acid
lipid peroxidation

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Biology
Nutrition and Dietetics
Clinical Biochemistry

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10.1016/0955-2863(96)00027-7

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title = "Status of lipids, lipid peroxidation, and antioxidant systems with vitamin C supplementation during aging in rats",

abstract = "Molecular mechanisms responsible for age-dependent deterioration of biochemical functions remain unclear. We determined the effect of ascorbic acid supplementation (20 mg/100 g body weight/day) in young and aged rats for 15, 30, and 60 days. In the aged animals cholesterol, triglycerides, phospholipids, and lipid peroxidation were considerably high, whereas, antioxidants superoxide dismutase, catalase, glutathione peroxidase, glutathione, ascorbic acid, and α-tocopherol were low. Administration of ascorbic acid reverted these age-associated differences to the status comparable to young rats.",

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AU - Jayachandran, M.

AU - Jayanthi, B.

AU - Sundaravadivel, B.

AU - Panneerselvam, C.

PY - 1996/5

Y1 - 1996/5

N2 - Molecular mechanisms responsible for age-dependent deterioration of biochemical functions remain unclear. We determined the effect of ascorbic acid supplementation (20 mg/100 g body weight/day) in young and aged rats for 15, 30, and 60 days. In the aged animals cholesterol, triglycerides, phospholipids, and lipid peroxidation were considerably high, whereas, antioxidants superoxide dismutase, catalase, glutathione peroxidase, glutathione, ascorbic acid, and α-tocopherol were low. Administration of ascorbic acid reverted these age-associated differences to the status comparable to young rats.

AB - Molecular mechanisms responsible for age-dependent deterioration of biochemical functions remain unclear. We determined the effect of ascorbic acid supplementation (20 mg/100 g body weight/day) in young and aged rats for 15, 30, and 60 days. In the aged animals cholesterol, triglycerides, phospholipids, and lipid peroxidation were considerably high, whereas, antioxidants superoxide dismutase, catalase, glutathione peroxidase, glutathione, ascorbic acid, and α-tocopherol were low. Administration of ascorbic acid reverted these age-associated differences to the status comparable to young rats.

KW - aging

KW - antioxidants

KW - ascorbic acid

KW - lipid peroxidation

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Status of lipids, lipid peroxidation, and antioxidant systems with vitamin C supplementation during aging in rats

Abstract

Keywords

ASJC Scopus subject areas

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