Status of lipids, lipid peroxidation, and antioxidant systems with vitamin C supplementation during aging in rats

M. Jayachandran, B. Jayanthi, B. Sundaravadivel, C. Panneerselvam

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Molecular mechanisms responsible for age-dependent deterioration of biochemical functions remain unclear. We determined the effect of ascorbic acid supplementation (20 mg/100 g body weight/day) in young and aged rats for 15, 30, and 60 days. In the aged animals cholesterol, triglycerides, phospholipids, and lipid peroxidation were considerably high, whereas, antioxidants superoxide dismutase, catalase, glutathione peroxidase, glutathione, ascorbic acid, and α-tocopherol were low. Administration of ascorbic acid reverted these age-associated differences to the status comparable to young rats.

Original languageEnglish (US)
Pages (from-to)270-275
Number of pages6
JournalJournal of Nutritional Biochemistry
Volume7
Issue number5
DOIs
StatePublished - May 1996

Keywords

  • aging
  • antioxidants
  • ascorbic acid
  • lipid peroxidation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Nutrition and Dietetics
  • Clinical Biochemistry

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