Standards of care for hypoparathyroidism in adults: A Canadian and international consensus

Aliya A. Khan, Christian A. Koch, Stan Van Uum, Jean Patrice Baillargeon, Jens Bollerslev, Maria Luisa Brandi, Claudio Marcocci, Lars Rejnmark, Rene Rizzoli, M. Zakarea Shrayyef, Rajesh Thakker, Bulent O. Yildiz, Bart Clarke

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Purpose: To provide practice recommendations for the diagnosis and management of hypoparathyroidism in adults. Methods: Key questions pertaining to the diagnosis and management of hypoparathyroidism were addressed following a literature review. We searched PubMed, MEDLINE, EMBASE and Cochrane databases from January 2000 to March 2018 using keywords 'hypoparathyroidism, diagnosis, treatment, calcium, PTH, calcidiol, calcitriol, hydrochlorothiazide and pregnancy'. Only English language papers involving humans were included. We excluded letters, reviews and editorials. The quality of evidence was evaluated based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. These standards of care for hypoparathyroidism have been endorsed by the Canadian Society of Endocrinology and Metabolism. Results: Hypoparathyroidism is a rare disease characterized by hypocalcemia, hyperphosphatemia and a low or inappropriately normal serum parathyroid hormone level (PTH). The majority of cases are post-surgical (75%) with nonsurgical causes accounting for the remaining 25% of cases. A careful review is required to determine the etiology of the hypoparathyroidism in individuals with nonsurgical disea se. Hypoparathyroidism is associated with significant morbidity and poor quality of life. Treatment requires close monitoring as well as patient education. Conventional therapy with calcium supplements and active vitamin D analogs i s effective in improving serum calcium as well as in controlling the symptoms of hypocalcemia. PTH replacement is of value in lowering the doses of calcium and active vitamin D analogs required and may be of value in lowering long-term complications of hypoparathyroidism. This manuscript addresses acute and chronic management of hypoparathyroidism in adults. Main conclusions: Hypoparathyroidism requires careful evaluation and pharmacologic intervention in order to improve serum calcium and control the symptoms of hypocalcemia. Frequen t laboratory monitoring of the biochemical profile and patient education is essential to achieving optimal control of serum calcium.

Original languageEnglish (US)
Pages (from-to)P1-P22
JournalEuropean journal of endocrinology
Volume180
Issue number3
DOIs
StatePublished - Mar 2019

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Khan, A. A., Koch, C. A., Van Uum, S., Baillargeon, J. P., Bollerslev, J., Brandi, M. L., Marcocci, C., Rejnmark, L., Rizzoli, R., Shrayyef, M. Z., Thakker, R., Yildiz, B. O., & Clarke, B. (2019). Standards of care for hypoparathyroidism in adults: A Canadian and international consensus. European journal of endocrinology, 180(3), P1-P22. https://doi.org/10.1530/EJE-18-0609