TY - JOUR
T1 - Squamous cell carcinoma in perineal, perianal, and gluteal hidradenitis suppurativa
T2 - Experience in 12 patients
AU - Kohorst, John J.
AU - Shah, Kabeer K.
AU - Hallemeier, Christopher L.
AU - Baum, Christian L.
AU - Davis, Mark D.P.
N1 - Publisher Copyright:
© 2018 by the American Society for Dermatologic Surgery, Inc.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - BACKGROUNDFew reports describe squamous cell carcinoma (SCC) arising in hidradenitis suppurativa (HS).OBJECTIVEThe 2 objectives were (1) to describe the clinical characteristics, pathologic findings, and postoperative outcomes of SCC in HS and (2) to assess whether human papillomavirus (HPV) is involved in the pathogenesis.MATERIALS AND METHODSCases of SCC in HS were identified through institutional medical records (1976-2013) and the Rochester Epidemiology Project. Tumor specimens were assessed for HPV DNA/RNA with in situ hybridization.RESULTSTwelve patients were identified (11 Caucasians and 9 men). All SCCs involved gluteal, perianal, or perineal skin; 1 patient had, in addition, involvement of the vagina. Surgical excision was performed on all 12 patients, 4 of whom had a colostomy. Mean duration of HS before SCC development was 28.5 years (range, 15-53 years). Mean follow-up was 4.3 years after surgical excision. Seven of 12 patients followed had postoperative SCC recurrence. Squamous cell carcinoma caused death despite wide surgical excision in these 7 patients. Of the remaining 5 patients, 4 are unknown and 1 who did not recur had an in situ SCC (Bowen disease carcinoma). Squamous cell carcinoma was not associated with high-risk or low-risk HPV.CONCLUSIONInvasive SCC arising in HS carries a high risk of death.
AB - BACKGROUNDFew reports describe squamous cell carcinoma (SCC) arising in hidradenitis suppurativa (HS).OBJECTIVEThe 2 objectives were (1) to describe the clinical characteristics, pathologic findings, and postoperative outcomes of SCC in HS and (2) to assess whether human papillomavirus (HPV) is involved in the pathogenesis.MATERIALS AND METHODSCases of SCC in HS were identified through institutional medical records (1976-2013) and the Rochester Epidemiology Project. Tumor specimens were assessed for HPV DNA/RNA with in situ hybridization.RESULTSTwelve patients were identified (11 Caucasians and 9 men). All SCCs involved gluteal, perianal, or perineal skin; 1 patient had, in addition, involvement of the vagina. Surgical excision was performed on all 12 patients, 4 of whom had a colostomy. Mean duration of HS before SCC development was 28.5 years (range, 15-53 years). Mean follow-up was 4.3 years after surgical excision. Seven of 12 patients followed had postoperative SCC recurrence. Squamous cell carcinoma caused death despite wide surgical excision in these 7 patients. Of the remaining 5 patients, 4 are unknown and 1 who did not recur had an in situ SCC (Bowen disease carcinoma). Squamous cell carcinoma was not associated with high-risk or low-risk HPV.CONCLUSIONInvasive SCC arising in HS carries a high risk of death.
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U2 - 10.1097/DSS.0000000000001713
DO - 10.1097/DSS.0000000000001713
M3 - Article
C2 - 30608295
AN - SCOPUS:85064239175
SN - 1076-0512
VL - 45
SP - 519
EP - 526
JO - Dermatologic Surgery
JF - Dermatologic Surgery
IS - 4
ER -