Spouses and unrelated friends of probands as controls for stroke genetics studies

Bradford Burke Worrall, Devin L. Brown, Thomas G Brott, Robert D Jr. Brown, Scott L. Silliman, James F Meschia

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

To plan a multisite, ischemic stroke genetic study, stroke patients were surveyed about the availability and characteristics of a convenience sample of spouse/friend controls. 65% of all stroke-affected probands reported a living spouse. A more detailed survey was conducted at the University of Virginia, Charlottesville, Va., USA: 51% of stroke patients reported a living, stroke-free spouse who would be willing to serve as a control, and 49% reported having a stroke-free friend who would be willing to serve as a control. Overall, 75% of stroke patients reported at least 1 individual willing to participate as a control. Cases without an identified control were more likely to be non-white (48%) than were cases with a control (13%; p = 0.00004). Cases were older than controls (67.3 vs. 59.2 years; p = 0.000002), and a greater proportion of cases than controls were male (57 vs. 33%; p = 0.0002). Without proper attention to matching, the use of a spouse/friend convenience sample would result in imbalances in basic demographic characteristics.

Original languageEnglish (US)
Pages (from-to)239-244
Number of pages6
JournalNeuroepidemiology
Volume22
Issue number4
DOIs
StatePublished - 2003

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Spouses
Stroke
Demography

Keywords

  • Case-control study
  • Design/methodology
  • Genetics
  • Ischemic stroke

ASJC Scopus subject areas

  • Epidemiology
  • Clinical Neurology

Cite this

Spouses and unrelated friends of probands as controls for stroke genetics studies. / Worrall, Bradford Burke; Brown, Devin L.; Brott, Thomas G; Brown, Robert D Jr.; Silliman, Scott L.; Meschia, James F.

In: Neuroepidemiology, Vol. 22, No. 4, 2003, p. 239-244.

Research output: Contribution to journalArticle

Worrall, Bradford Burke ; Brown, Devin L. ; Brott, Thomas G ; Brown, Robert D Jr. ; Silliman, Scott L. ; Meschia, James F. / Spouses and unrelated friends of probands as controls for stroke genetics studies. In: Neuroepidemiology. 2003 ; Vol. 22, No. 4. pp. 239-244.
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