Splanchnic free fatty acid kinetics

Michael Dennis Jensen, Sylvain Cardin, Dale Edgerton, Alan Cherrington

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

These studies were conducted to assess the relationship between visceral adipose tissue free fatty acid (FFA) release and splanchnic FFA release. Steady-state splanchnic bed palmitate ([9,10-3H]palmitate) kinetics were determined from 14 sampling intervals from eight dogs with chronic indwelling arterial, portal vein, and hepatic vein catheters. We tested a model designed to predict the proportion of FFAs delivered to the liver from visceral fat by use of hepatic vein data. The model predicted that 15 ± 2% of hepatic palmitate delivery originated from visceral lipolysis, which was greater (P = 0.004) than the 11 ± 2% actually observed. There was a good relationship (r2 = 0.63) between the predicted and observed hepatic palmitate delivery values, but the model overestimated visceral FFA release more at lower than at higher palmitate concentrations. The discrepancy could be due to differential uptake of FFAs arriving from the arterial vs. the portal vein or to release of FFAs in the hepatic circulatory bed. Splanchnic FFA release measured using hepatic vein samples was strongly related to visceral adipose tissue FFA release into the portal vein. This finding suggests that splanchnic FFA release is a good indicator of visceral adipose tissue lipolysis.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume284
Issue number6 47-6
StatePublished - Jun 1 2003

Fingerprint

Viscera
Nonesterified Fatty Acids
Palmitates
Intra-Abdominal Fat
Kinetics
Hepatic Veins
Portal Vein
Lipolysis
Liver
Tissue
Catheters
Fats
Dogs
Sampling

Keywords

  • Isotope tracers
  • Kinetic model
  • Lipolysis

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry

Cite this

Splanchnic free fatty acid kinetics. / Jensen, Michael Dennis; Cardin, Sylvain; Edgerton, Dale; Cherrington, Alan.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 284, No. 6 47-6, 01.06.2003.

Research output: Contribution to journalArticle

Jensen, MD, Cardin, S, Edgerton, D & Cherrington, A 2003, 'Splanchnic free fatty acid kinetics', American Journal of Physiology - Endocrinology and Metabolism, vol. 284, no. 6 47-6.
Jensen, Michael Dennis ; Cardin, Sylvain ; Edgerton, Dale ; Cherrington, Alan. / Splanchnic free fatty acid kinetics. In: American Journal of Physiology - Endocrinology and Metabolism. 2003 ; Vol. 284, No. 6 47-6.
@article{6c7f474063ff4daebce8481b07b76ae9,
title = "Splanchnic free fatty acid kinetics",
abstract = "These studies were conducted to assess the relationship between visceral adipose tissue free fatty acid (FFA) release and splanchnic FFA release. Steady-state splanchnic bed palmitate ([9,10-3H]palmitate) kinetics were determined from 14 sampling intervals from eight dogs with chronic indwelling arterial, portal vein, and hepatic vein catheters. We tested a model designed to predict the proportion of FFAs delivered to the liver from visceral fat by use of hepatic vein data. The model predicted that 15 ± 2{\%} of hepatic palmitate delivery originated from visceral lipolysis, which was greater (P = 0.004) than the 11 ± 2{\%} actually observed. There was a good relationship (r2 = 0.63) between the predicted and observed hepatic palmitate delivery values, but the model overestimated visceral FFA release more at lower than at higher palmitate concentrations. The discrepancy could be due to differential uptake of FFAs arriving from the arterial vs. the portal vein or to release of FFAs in the hepatic circulatory bed. Splanchnic FFA release measured using hepatic vein samples was strongly related to visceral adipose tissue FFA release into the portal vein. This finding suggests that splanchnic FFA release is a good indicator of visceral adipose tissue lipolysis.",
keywords = "Isotope tracers, Kinetic model, Lipolysis",
author = "Jensen, {Michael Dennis} and Sylvain Cardin and Dale Edgerton and Alan Cherrington",
year = "2003",
month = "6",
day = "1",
language = "English (US)",
volume = "284",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "6 47-6",

}

TY - JOUR

T1 - Splanchnic free fatty acid kinetics

AU - Jensen, Michael Dennis

AU - Cardin, Sylvain

AU - Edgerton, Dale

AU - Cherrington, Alan

PY - 2003/6/1

Y1 - 2003/6/1

N2 - These studies were conducted to assess the relationship between visceral adipose tissue free fatty acid (FFA) release and splanchnic FFA release. Steady-state splanchnic bed palmitate ([9,10-3H]palmitate) kinetics were determined from 14 sampling intervals from eight dogs with chronic indwelling arterial, portal vein, and hepatic vein catheters. We tested a model designed to predict the proportion of FFAs delivered to the liver from visceral fat by use of hepatic vein data. The model predicted that 15 ± 2% of hepatic palmitate delivery originated from visceral lipolysis, which was greater (P = 0.004) than the 11 ± 2% actually observed. There was a good relationship (r2 = 0.63) between the predicted and observed hepatic palmitate delivery values, but the model overestimated visceral FFA release more at lower than at higher palmitate concentrations. The discrepancy could be due to differential uptake of FFAs arriving from the arterial vs. the portal vein or to release of FFAs in the hepatic circulatory bed. Splanchnic FFA release measured using hepatic vein samples was strongly related to visceral adipose tissue FFA release into the portal vein. This finding suggests that splanchnic FFA release is a good indicator of visceral adipose tissue lipolysis.

AB - These studies were conducted to assess the relationship between visceral adipose tissue free fatty acid (FFA) release and splanchnic FFA release. Steady-state splanchnic bed palmitate ([9,10-3H]palmitate) kinetics were determined from 14 sampling intervals from eight dogs with chronic indwelling arterial, portal vein, and hepatic vein catheters. We tested a model designed to predict the proportion of FFAs delivered to the liver from visceral fat by use of hepatic vein data. The model predicted that 15 ± 2% of hepatic palmitate delivery originated from visceral lipolysis, which was greater (P = 0.004) than the 11 ± 2% actually observed. There was a good relationship (r2 = 0.63) between the predicted and observed hepatic palmitate delivery values, but the model overestimated visceral FFA release more at lower than at higher palmitate concentrations. The discrepancy could be due to differential uptake of FFAs arriving from the arterial vs. the portal vein or to release of FFAs in the hepatic circulatory bed. Splanchnic FFA release measured using hepatic vein samples was strongly related to visceral adipose tissue FFA release into the portal vein. This finding suggests that splanchnic FFA release is a good indicator of visceral adipose tissue lipolysis.

KW - Isotope tracers

KW - Kinetic model

KW - Lipolysis

UR - http://www.scopus.com/inward/record.url?scp=0037502839&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037502839&partnerID=8YFLogxK

M3 - Article

C2 - 12736157

AN - SCOPUS:0037502839

VL - 284

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 6 47-6

ER -