Spine Disorders and Regenerative Rehabilitation

Eva Kubrova; Andre J. van Wijnen; Wenchun Qu

doi:10.1007/s40141-019-00252-5

Spine Disorders and Regenerative Rehabilitation

Eva Kubrova, Andre J. van Wijnen, Wenchun Qu

Research output: Contribution to journal › Review article › peer-review

Abstract

Purpose of Review: The purpose of this review is to evaluate recent advancements in regenerative medicine modalities in the treatment of the most common spinal disorders. Recent Findings: Immunomodulatory and trophic effects of the mesenchymal stem cells (MSCs), platelet-rich plasma (PRP), and growth factors have been studied in the treatment of symptomatic degenerative spine disorders including degenerative disc disease and facet joint arthropathy. Gene therapy and exosomes are investigated as a future generation of biologics with gene therapy most advanced in the treatment of osteoarthritis. Summary: While current studies have shown benefit in pain and function using MSCs and PRP treatment for common spine conditions, high-quality controlled clinical trials are needed for assessing the safety and effectiveness of biologics.

Original language	English (US)
Pages (from-to)	30-36
Number of pages	7
Journal	Current Physical Medicine and Rehabilitation Reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1007/s40141-019-00252-5
State	Published - Mar 1 2020

Keywords

Degenerative disc
Facet joint
Gene therapy
Growth factors
Mesenchymal stem cells
Platelet-rich plasma

ASJC Scopus subject areas

Rehabilitation
Physical Therapy, Sports Therapy and Rehabilitation
Medicine (miscellaneous)
Orthopedics and Sports Medicine

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10.1007/s40141-019-00252-5

Cite this

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abstract = "Purpose of Review: The purpose of this review is to evaluate recent advancements in regenerative medicine modalities in the treatment of the most common spinal disorders. Recent Findings: Immunomodulatory and trophic effects of the mesenchymal stem cells (MSCs), platelet-rich plasma (PRP), and growth factors have been studied in the treatment of symptomatic degenerative spine disorders including degenerative disc disease and facet joint arthropathy. Gene therapy and exosomes are investigated as a future generation of biologics with gene therapy most advanced in the treatment of osteoarthritis. Summary: While current studies have shown benefit in pain and function using MSCs and PRP treatment for common spine conditions, high-quality controlled clinical trials are needed for assessing the safety and effectiveness of biologics.",

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AU - Kubrova, Eva

AU - van Wijnen, Andre J.

AU - Qu, Wenchun

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N2 - Purpose of Review: The purpose of this review is to evaluate recent advancements in regenerative medicine modalities in the treatment of the most common spinal disorders. Recent Findings: Immunomodulatory and trophic effects of the mesenchymal stem cells (MSCs), platelet-rich plasma (PRP), and growth factors have been studied in the treatment of symptomatic degenerative spine disorders including degenerative disc disease and facet joint arthropathy. Gene therapy and exosomes are investigated as a future generation of biologics with gene therapy most advanced in the treatment of osteoarthritis. Summary: While current studies have shown benefit in pain and function using MSCs and PRP treatment for common spine conditions, high-quality controlled clinical trials are needed for assessing the safety and effectiveness of biologics.

AB - Purpose of Review: The purpose of this review is to evaluate recent advancements in regenerative medicine modalities in the treatment of the most common spinal disorders. Recent Findings: Immunomodulatory and trophic effects of the mesenchymal stem cells (MSCs), platelet-rich plasma (PRP), and growth factors have been studied in the treatment of symptomatic degenerative spine disorders including degenerative disc disease and facet joint arthropathy. Gene therapy and exosomes are investigated as a future generation of biologics with gene therapy most advanced in the treatment of osteoarthritis. Summary: While current studies have shown benefit in pain and function using MSCs and PRP treatment for common spine conditions, high-quality controlled clinical trials are needed for assessing the safety and effectiveness of biologics.

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KW - Facet joint

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Spine Disorders and Regenerative Rehabilitation

Abstract

Keywords

ASJC Scopus subject areas

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