Sphincter-preserving radiation therapy for rectal cancer: A simulation study using three-dimensional computerized technology

P. Gervaz, S. Lavertu, B. Kazemba, John H. Pemberton, Michael Haddock, L. L. Gunderson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The acquisition of detailed computerized tomography (CT) imaging at the time of simulation, along with three-dimensional (3D) treatment planning software has been integrated with radiation delivery hardware to create the modality known as 3D conformal radiotherapy (3DXRT). This approach provides, in theory, a means to selectively subtract the anal sphincter from the high-dose field of irradiation in patients with stage II and III adenocarcinomas of the mid-rectum scheduled for low anterior resection (LAR). Hypothesis: Implementation of 3DXRT with sphincter blocking may be a feasible strategy to reduce the dose of radiation distributed to the anal canal without reduction in the dose distribution to the gross tumour volume (GTV) plus adequate margins. Methods: Pretreatment simulation CT scans of 10 patients with rectal cancers located between 5 and 10 cm from the anal verge were retrieved from a computerized database. Radiation oncologists and colorectal surgeons defined the contours of the GTV and the anal sphincter, respectively, on successive CT scan slices. These contours provided the volumetric data required to quantify dose distribution and compute dose-volume histograms. The standard mode of pelvic irradiation planned with CT simulation was compared with a 'virtual CT simulation' approach, in which a sphincter block was added to the protocol. Results: The mean distance of tumours from the anal verge was 6.3 cm. In the virtual simulation treatment plan, a 2-cm margin separated the sphincter block from the lower limit of the GTV. The mean volume of the anal sphincter was 16.1 ± 3.5 cm 3. The dose distributed to the GTV in the real plan and in the virtual simulated block plan were 51.7 ± 1.4 and 51.6 ± 1.4 Gy respectively (P = 0.85). By comparison the mean dose distributed to the anal sphincter was dramatically reduced by using a sphincter block (33.2 ± 12 Gy vs 6.4 ± 4.1Gy, P < 0.001). Conclusion: During a course of radio therapy for most low- or mid-rectal cancers, the anal canal is included within the field of irradiation with a mean dose distribution to the sphincter of 33 Gy. Evaluation of 3DXRT with full sphincter block (mid-rectum) and partial sphincter block (distal rectum) is a feasible strategy to decrease the volume of anal sphincter carried to full dose without reduction in dose to the GTV. This approach, by minimizing treatment-induced damage to the anal sphincter, might improve functional outcome of LAR.

Original languageEnglish (US)
Pages (from-to)570-574
Number of pages5
JournalColorectal Disease
Volume8
Issue number7
DOIs
StatePublished - Sep 2006

Fingerprint

Anal Canal
Rectal Neoplasms
Radiotherapy
Technology
Tumor Burden
Tomography
Rectum
Radiation
Conformal Radiotherapy
Radio
Adenocarcinoma
Therapeutics
Software
Databases

Keywords

  • Anal sphincter
  • Computer
  • Conformal
  • Dose-volume histogram
  • Radiation
  • Rectal cancer

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Sphincter-preserving radiation therapy for rectal cancer : A simulation study using three-dimensional computerized technology. / Gervaz, P.; Lavertu, S.; Kazemba, B.; Pemberton, John H.; Haddock, Michael; Gunderson, L. L.

In: Colorectal Disease, Vol. 8, No. 7, 09.2006, p. 570-574.

Research output: Contribution to journalArticle

Gervaz, P. ; Lavertu, S. ; Kazemba, B. ; Pemberton, John H. ; Haddock, Michael ; Gunderson, L. L. / Sphincter-preserving radiation therapy for rectal cancer : A simulation study using three-dimensional computerized technology. In: Colorectal Disease. 2006 ; Vol. 8, No. 7. pp. 570-574.
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abstract = "Background: The acquisition of detailed computerized tomography (CT) imaging at the time of simulation, along with three-dimensional (3D) treatment planning software has been integrated with radiation delivery hardware to create the modality known as 3D conformal radiotherapy (3DXRT). This approach provides, in theory, a means to selectively subtract the anal sphincter from the high-dose field of irradiation in patients with stage II and III adenocarcinomas of the mid-rectum scheduled for low anterior resection (LAR). Hypothesis: Implementation of 3DXRT with sphincter blocking may be a feasible strategy to reduce the dose of radiation distributed to the anal canal without reduction in the dose distribution to the gross tumour volume (GTV) plus adequate margins. Methods: Pretreatment simulation CT scans of 10 patients with rectal cancers located between 5 and 10 cm from the anal verge were retrieved from a computerized database. Radiation oncologists and colorectal surgeons defined the contours of the GTV and the anal sphincter, respectively, on successive CT scan slices. These contours provided the volumetric data required to quantify dose distribution and compute dose-volume histograms. The standard mode of pelvic irradiation planned with CT simulation was compared with a 'virtual CT simulation' approach, in which a sphincter block was added to the protocol. Results: The mean distance of tumours from the anal verge was 6.3 cm. In the virtual simulation treatment plan, a 2-cm margin separated the sphincter block from the lower limit of the GTV. The mean volume of the anal sphincter was 16.1 ± 3.5 cm 3. The dose distributed to the GTV in the real plan and in the virtual simulated block plan were 51.7 ± 1.4 and 51.6 ± 1.4 Gy respectively (P = 0.85). By comparison the mean dose distributed to the anal sphincter was dramatically reduced by using a sphincter block (33.2 ± 12 Gy vs 6.4 ± 4.1Gy, P < 0.001). Conclusion: During a course of radio therapy for most low- or mid-rectal cancers, the anal canal is included within the field of irradiation with a mean dose distribution to the sphincter of 33 Gy. Evaluation of 3DXRT with full sphincter block (mid-rectum) and partial sphincter block (distal rectum) is a feasible strategy to decrease the volume of anal sphincter carried to full dose without reduction in dose to the GTV. This approach, by minimizing treatment-induced damage to the anal sphincter, might improve functional outcome of LAR.",
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AU - Lavertu, S.

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AU - Pemberton, John H.

AU - Haddock, Michael

AU - Gunderson, L. L.

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KW - Conformal

KW - Dose-volume histogram

KW - Radiation

KW - Rectal cancer

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