Spectrum of diseases associated with increased proportions or absolute numbers of peripheral blood natural killer cells

Scott H. Okuno, Ayalew Tefferi, Curtis A. Hanson, Jerry A. Katzmann, Chin Yang Li, Thomas E. Witzig

Research output: Contribution to journalArticle

24 Scopus citations


In a retrospective review of 1501 lymphoid fiow cytometric studies of peripheral blood, we identified an increased proportion of natural killer cells in 125 cases (8%), 49 (3%) of which had a concomitant increase in absolute number of natural killer cells. Of the latter, the most frequent associated disorder was chronic natural killer cell lymphocytosis. Substantial quantitative increases in natural killer cells were also observed in some patients with lymphoma, leukaemia, immune thrombocytopenic purpura, or myelodysplastic syndrome. Our study provides incidence figures and clinical associations of an increased number of natural killer cells in the peripheral blood.

Original languageEnglish (US)
Pages (from-to)810-812
Number of pages3
JournalBritish journal of haematology
Issue number4
StatePublished - Jul 2 1996



  • flow cytometry
  • leukaemia
  • lymphocytes
  • natural killer cells
  • peripheral blood

ASJC Scopus subject areas

  • Hematology

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