Spectroscopic increase in choline signal is a nonspecific marker for differentiation of infective/inflammatory from neoplastic lesions of the brain

Sudhakar K. Venkatesh, Rakesh K. Gupta, Lily Pal, Nuzhat Husain, Mazhar Husain

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

We report in vivo proton magnetic resonance (MR) spectroscopic findings in three benign infective/inflammatory lesions (one case each of tuberculoma, fungal granuloma, and xanthogranuloma), which showed high choline along with the presence of lipid/lactate, a feature characteristically described in neoplastic lesions. Histopathology of the lesions showed inflammatory cellular infiltrates with areas of necrosis/caseation. The spectroscopic-visible increased choline resonance in these lesions is probably the result of cellularity. We conclude that increased choline, along with the presence of lipid/lactate is a nonspecific finding and may not be of much value in the differentiation of neoplastic from nonneoplastic infective/inflammatory intracranial mass lesions.

Original languageEnglish (US)
Pages (from-to)8-15
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume14
Issue number1
DOIs
StatePublished - 2001

Keywords

  • Brain
  • Fungal granuloma
  • MR spectroscopy
  • Tuberculoma
  • Xanthogranuloma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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