TY - GEN
T1 - Spectral compensation for tissue attenuation and transmit intensity in ultrasonic detection of microbubbles by harmonic method
AU - Chen, Shigao
AU - Fatemi, Mostafa
AU - McMahon, Eileen
AU - Greenleaf, James F.
AU - Belohlavek, Marek
PY - 2004
Y1 - 2004
N2 - Tissue perfusion can be assessed by harmonic imaging of microbubbles which are highly nonlinear and produce strong harmonic component as they scatter the incident ultrasound. However, the harmonic magnitude also depends on the pressure of the transmitted ultrasound and the attenuation of the intervening tissues in the ultrasound path. Thus the harmonic magnitude may not be a reliable indicator of the presence or absence of microbubbles. and hence, tissue perfusion. Here, we propose a parameter called Harmonic to Squared Fundamental Ratio (HSFR) that, under ideal condition, completely compensates for the effects of tissue attenuation and transmit pressure for superior microbubble detection. In experiments, the target tested is 0.01% microbubble solution or water (as a control). The echoes from these targets obtained with different transmit pressures and attenuation pads are used to compute the HSFR. HSFR is able to separate the microbubble solutions from the control with a single threshold for all combinations of attenuation and transmit intensity tested.
AB - Tissue perfusion can be assessed by harmonic imaging of microbubbles which are highly nonlinear and produce strong harmonic component as they scatter the incident ultrasound. However, the harmonic magnitude also depends on the pressure of the transmitted ultrasound and the attenuation of the intervening tissues in the ultrasound path. Thus the harmonic magnitude may not be a reliable indicator of the presence or absence of microbubbles. and hence, tissue perfusion. Here, we propose a parameter called Harmonic to Squared Fundamental Ratio (HSFR) that, under ideal condition, completely compensates for the effects of tissue attenuation and transmit pressure for superior microbubble detection. In experiments, the target tested is 0.01% microbubble solution or water (as a control). The echoes from these targets obtained with different transmit pressures and attenuation pads are used to compute the HSFR. HSFR is able to separate the microbubble solutions from the control with a single threshold for all combinations of attenuation and transmit intensity tested.
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U2 - 10.1109/ULTSYM.2004.1417927
DO - 10.1109/ULTSYM.2004.1417927
M3 - Conference contribution
AN - SCOPUS:21644447554
SN - 0780384121
T3 - Proceedings - IEEE Ultrasonics Symposium
SP - 982
EP - 985
BT - Proceedings - 2004 IEEE Ultrasonics Symposium
A2 - Yuhas, M.P.
T2 - 2004 IEEE Ultrasonics Symposium
Y2 - 23 August 2004 through 27 August 2004
ER -