Spectral compensation for tissue attenuation and transmit intensity in ultrasonic detection of microbubbles by harmonic method

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Tissue perfusion can be assessed by harmonic imaging of microbubbles which are highly nonlinear and produce strong harmonic component as they scatter the incident ultrasound. However, the harmonic magnitude also depends on the pressure of the transmitted ultrasound and the attenuation of the intervening tissues in the ultrasound path. Thus the harmonic magnitude may not be a reliable indicator of the presence or absence of microbubbles. and hence, tissue perfusion. Here, we propose a parameter called Harmonic to Squared Fundamental Ratio (HSFR) that, under ideal condition, completely compensates for the effects of tissue attenuation and transmit pressure for superior microbubble detection. In experiments, the target tested is 0.01% microbubble solution or water (as a control). The echoes from these targets obtained with different transmit pressures and attenuation pads are used to compute the HSFR. HSFR is able to separate the microbubble solutions from the control with a single threshold for all combinations of attenuation and transmit intensity tested.

Original languageEnglish (US)
Title of host publicationProceedings - 2004 IEEE Ultrasonics Symposium
Subtitle of host publicationA Conference of the IEEE International Ultrasonics, Ferroelectrics, and Frequency Control Society, UFFC-S
EditorsM.P. Yuhas
Pages982-985
Number of pages4
DOIs
StatePublished - Dec 1 2004
Event2004 IEEE Ultrasonics Symposium - Montreal, Que., Canada
Duration: Aug 23 2004Aug 27 2004

Publication series

NameProceedings - IEEE Ultrasonics Symposium
Volume2
ISSN (Print)1051-0117

Other

Other2004 IEEE Ultrasonics Symposium
CountryCanada
CityMontreal, Que.
Period8/23/048/27/04

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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    Chen, S., Fatemi, M., McMahon, E., Greenleaf, J. F., & Belohlavek, M. (2004). Spectral compensation for tissue attenuation and transmit intensity in ultrasonic detection of microbubbles by harmonic method. In M. P. Yuhas (Ed.), Proceedings - 2004 IEEE Ultrasonics Symposium: A Conference of the IEEE International Ultrasonics, Ferroelectrics, and Frequency Control Society, UFFC-S (pp. 982-985). [U1-I-2] (Proceedings - IEEE Ultrasonics Symposium; Vol. 2). https://doi.org/10.1109/ULTSYM.2004.1417927