Species marker for developing novel and safe pesticides

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Current anticholinesterase pesticides developed during World War II are toxic to mammals because they target a catalytic serine residue of acetylcholinesterases (AChEs) in insects and in mammals. A sequence analysis of AChEs from 68 species and three-dimensional models of the greenbug and English grain aphid AChEs reported herein reveal that a cysteine residue is present at the active sites of greenbug and aphid AChEs but absent at those of mammalian AChEs. This discovery enables the design of novel and safe pesticides that target the cysteine residue rather than the ubiquitous serine residue.

Original languageEnglish (US)
Pages (from-to)197-199
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number1
DOIs
StatePublished - Jan 1 2007

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Keywords

  • Cholinesterase
  • Crop damage
  • Insecticides
  • Irreversible inhibitors
  • Structure-based inhibitor design

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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