Sofosbuvir and simeprevir combination therapy in the setting of liver transplantation and hemodialysis

R. B. Perumpail, R. J. Wong, L. D. Ha, E. A. Pham, U. Wang, H. Luong, R. Kumari, T. J. Daugherty, J. P. Higgins, Z. M. Younossi, W. R. Kim, J. S. Glenn, A. Ahmed

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

We report safety, tolerability, and 12-week sustained virologic response with half-standard dose sofosbuvir and standard-dose simeprevir combination therapy in a hepatitis C virus genotype 1a-infected liver transplant recipient on hemodialysis - uncharted territory for sofosbuvir-based therapy. The patient was a non-responder to prior treatment with pegylated interferon plus ribavirin. Sofosbuvir efficacy was maintained despite pill-splitting and administration of half-standard dose, 200 mg per day. No drug-drug interactions were noted with tacrolimus-based immunosuppression. Laboratory tests remained stable or improved during therapy. Our observation, if reproduced in a larger study, may lead to significant improvement in clinical outcomes and cost savings in this patient population.

Original languageEnglish (US)
Pages (from-to)275-278
Number of pages4
JournalTransplant Infectious Disease
Volume17
Issue number2
DOIs
StatePublished - Apr 1 2015

Keywords

  • Direct-acting antivirals
  • Hemodialysis
  • Hepatitis C virus
  • Liver transplantation
  • Simeprevir
  • Sofosbuvir

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation

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    Perumpail, R. B., Wong, R. J., Ha, L. D., Pham, E. A., Wang, U., Luong, H., Kumari, R., Daugherty, T. J., Higgins, J. P., Younossi, Z. M., Kim, W. R., Glenn, J. S., & Ahmed, A. (2015). Sofosbuvir and simeprevir combination therapy in the setting of liver transplantation and hemodialysis. Transplant Infectious Disease, 17(2), 275-278. https://doi.org/10.1111/tid.12348