Sodium-lithium countertransport and blood pressure in healthy blood donors

Stephen T Turner, Mark Johnson, Eric Boerwinkle, Elliott Richelson, Howard F. Taswell, Charles F. Sing

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Studies finding an increased maximal rate of Na-Li countertransport in red blood cells from persons with essential hypertension and their normotensive offspring have raised the possibility that Na-Li countertransport may serve as a marker for the genetic predisposition to hypertension. We studied Na-Li countertransport in 238 randomly selected blood donors representative of the population of Rochester, Minnesota. The mean value (± SD) for Na-Li countertransport in units of mmoles of lithium efflux per liter of red blood cells per hour was 0.29 ± 0.12. The distribution of Na-Li countertransport values among the donors was continuous. An analysis for multimodality, however, detected significant evidence of bimodality with 72 % of the population predicted to belong to the lower mode with a mean of 0.24 mmol/L red blood cells per hour and 28% of the population to belong to the upper mode with a mean of 0.42 mmol/L red blood cells per hour. There was a positive association between Na-Li countertransport and blood pressure; after adjustment for weight and age, Na-Li countertransport predicted approximately 3% of the variation in blood pressure. Persons belonging to the upper mode of the Na-Li countertransport distribution may be at increased risk of acquiring elevated blood pressure as they age.

Original languageEnglish (US)
Pages (from-to)955-962
Number of pages8
JournalDimensions of Critical Care Nursing
Volume7
Issue number6
StatePublished - 1985

Fingerprint

Blood Donors
Lithium
Erythrocytes
Sodium
Blood Pressure
Population
Genetic Predisposition to Disease
Tissue Donors
Hypertension
Weights and Measures

Keywords

  • Hypertension
  • Membrane transport
  • Red blood cell

ASJC Scopus subject areas

  • Critical Care
  • Emergency

Cite this

Turner, S. T., Johnson, M., Boerwinkle, E., Richelson, E., Taswell, H. F., & Sing, C. F. (1985). Sodium-lithium countertransport and blood pressure in healthy blood donors. Dimensions of Critical Care Nursing, 7(6), 955-962.

Sodium-lithium countertransport and blood pressure in healthy blood donors. / Turner, Stephen T; Johnson, Mark; Boerwinkle, Eric; Richelson, Elliott; Taswell, Howard F.; Sing, Charles F.

In: Dimensions of Critical Care Nursing, Vol. 7, No. 6, 1985, p. 955-962.

Research output: Contribution to journalArticle

Turner, ST, Johnson, M, Boerwinkle, E, Richelson, E, Taswell, HF & Sing, CF 1985, 'Sodium-lithium countertransport and blood pressure in healthy blood donors', Dimensions of Critical Care Nursing, vol. 7, no. 6, pp. 955-962.
Turner ST, Johnson M, Boerwinkle E, Richelson E, Taswell HF, Sing CF. Sodium-lithium countertransport and blood pressure in healthy blood donors. Dimensions of Critical Care Nursing. 1985;7(6):955-962.
Turner, Stephen T ; Johnson, Mark ; Boerwinkle, Eric ; Richelson, Elliott ; Taswell, Howard F. ; Sing, Charles F. / Sodium-lithium countertransport and blood pressure in healthy blood donors. In: Dimensions of Critical Care Nursing. 1985 ; Vol. 7, No. 6. pp. 955-962.
@article{6d90233800a64d329fbfaac5292ffd8a,
title = "Sodium-lithium countertransport and blood pressure in healthy blood donors",
abstract = "Studies finding an increased maximal rate of Na-Li countertransport in red blood cells from persons with essential hypertension and their normotensive offspring have raised the possibility that Na-Li countertransport may serve as a marker for the genetic predisposition to hypertension. We studied Na-Li countertransport in 238 randomly selected blood donors representative of the population of Rochester, Minnesota. The mean value (± SD) for Na-Li countertransport in units of mmoles of lithium efflux per liter of red blood cells per hour was 0.29 ± 0.12. The distribution of Na-Li countertransport values among the donors was continuous. An analysis for multimodality, however, detected significant evidence of bimodality with 72 {\%} of the population predicted to belong to the lower mode with a mean of 0.24 mmol/L red blood cells per hour and 28{\%} of the population to belong to the upper mode with a mean of 0.42 mmol/L red blood cells per hour. There was a positive association between Na-Li countertransport and blood pressure; after adjustment for weight and age, Na-Li countertransport predicted approximately 3{\%} of the variation in blood pressure. Persons belonging to the upper mode of the Na-Li countertransport distribution may be at increased risk of acquiring elevated blood pressure as they age.",
keywords = "Hypertension, Membrane transport, Red blood cell",
author = "Turner, {Stephen T} and Mark Johnson and Eric Boerwinkle and Elliott Richelson and Taswell, {Howard F.} and Sing, {Charles F.}",
year = "1985",
language = "English (US)",
volume = "7",
pages = "955--962",
journal = "Dimensions of Critical Care Nursing",
issn = "0730-4625",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Sodium-lithium countertransport and blood pressure in healthy blood donors

AU - Turner, Stephen T

AU - Johnson, Mark

AU - Boerwinkle, Eric

AU - Richelson, Elliott

AU - Taswell, Howard F.

AU - Sing, Charles F.

PY - 1985

Y1 - 1985

N2 - Studies finding an increased maximal rate of Na-Li countertransport in red blood cells from persons with essential hypertension and their normotensive offspring have raised the possibility that Na-Li countertransport may serve as a marker for the genetic predisposition to hypertension. We studied Na-Li countertransport in 238 randomly selected blood donors representative of the population of Rochester, Minnesota. The mean value (± SD) for Na-Li countertransport in units of mmoles of lithium efflux per liter of red blood cells per hour was 0.29 ± 0.12. The distribution of Na-Li countertransport values among the donors was continuous. An analysis for multimodality, however, detected significant evidence of bimodality with 72 % of the population predicted to belong to the lower mode with a mean of 0.24 mmol/L red blood cells per hour and 28% of the population to belong to the upper mode with a mean of 0.42 mmol/L red blood cells per hour. There was a positive association between Na-Li countertransport and blood pressure; after adjustment for weight and age, Na-Li countertransport predicted approximately 3% of the variation in blood pressure. Persons belonging to the upper mode of the Na-Li countertransport distribution may be at increased risk of acquiring elevated blood pressure as they age.

AB - Studies finding an increased maximal rate of Na-Li countertransport in red blood cells from persons with essential hypertension and their normotensive offspring have raised the possibility that Na-Li countertransport may serve as a marker for the genetic predisposition to hypertension. We studied Na-Li countertransport in 238 randomly selected blood donors representative of the population of Rochester, Minnesota. The mean value (± SD) for Na-Li countertransport in units of mmoles of lithium efflux per liter of red blood cells per hour was 0.29 ± 0.12. The distribution of Na-Li countertransport values among the donors was continuous. An analysis for multimodality, however, detected significant evidence of bimodality with 72 % of the population predicted to belong to the lower mode with a mean of 0.24 mmol/L red blood cells per hour and 28% of the population to belong to the upper mode with a mean of 0.42 mmol/L red blood cells per hour. There was a positive association between Na-Li countertransport and blood pressure; after adjustment for weight and age, Na-Li countertransport predicted approximately 3% of the variation in blood pressure. Persons belonging to the upper mode of the Na-Li countertransport distribution may be at increased risk of acquiring elevated blood pressure as they age.

KW - Hypertension

KW - Membrane transport

KW - Red blood cell

UR - http://www.scopus.com/inward/record.url?scp=84929967040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929967040&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 955

EP - 962

JO - Dimensions of Critical Care Nursing

JF - Dimensions of Critical Care Nursing

SN - 0730-4625

IS - 6

ER -