SNPs near the cysteine proteinase cathepsin O gene (CTSO) determine tamoxifen sensitivity in ERα-positive breast cancer through regulation of BRCA1

Agriculture & Biology

• cathepsin O 100%
• tamoxifen 67%
• cysteine proteinases 56%
• breast neoplasms 55%
• estrogen receptors 55%
• genes 16%
• genotype 9%
• therapeutics 8%
• drugs 7%
• drug resistance 6%
• luciferase 6%
• assays 5%
• proteins 5%
• in vitro studies 5%
• neoplasm cells 4%
• biomarkers 4%
• cell proliferation 4%
• mass spectrometry 4%
• transcription factors 4%
• cell lines 4%
• genomics 3%
• degradation 3%
• cells 1%

Medicine & Life Sciences

• Cathepsins 65%
• Cysteine Proteases 60%
• Tamoxifen 51%
• Estrogen Receptors 45%
• Single Nucleotide Polymorphism 41%
• Breast Neoplasms 31%
• Genes 19%
• Genotype 13%
• BRCA1 Protein 9%
• Poly(ADP-ribose) Polymerase Inhibitors 8%
• Genome-Wide Association Study 6%
• Luciferases 5%
• Drug Resistance 5%
• Mass Spectrometry 5%
• Transcription Factors 4%
• Proteins 4%
• Cell Proliferation 4%
• Biomarkers 3%
• Cell Line 3%
• Growth 3%
• In Vitro Techniques 2%
• Pharmaceutical Preparations 2%
• Therapeutics 2%

Earth & Environmental Sciences

• cancer 45%
• gene 37%
• regulation 34%
• genotype 17%
• cell 13%
• protein 11%
• therapy 11%
• assay 9%
• drug 8%
• drug resistance 8%
• growth response 6%
• genomics 5%
• biomarker 5%
• genome 5%
• inhibitor 5%
• mass spectrometry 4%
• trial 4%
• degradation 3%
• effect 1%