TY - JOUR
T1 - I1 fumo, la pressione arteriosa e l'albuminemia sono fattori predittivi indipendenti del danno vascolare negli uremici in dialisi
AU - Benedetto, F. A.
AU - Bellanuova, I.
AU - Caridi, G.
AU - Rapisarda, F.
AU - Fatuzzo, P.
AU - Bonanno, G.
AU - Seminara, G.
AU - Cataliotti, A.
AU - Stancanelli, B.
AU - Cutrupi, S.
AU - Parlongo, S.
AU - Mallamaci, F.
AU - Tripepi, G.
AU - Marino, C.
AU - Panuccio, V.
AU - Candela, V.
AU - Garozzo, M.
AU - Tassone, F.
AU - Labate, C.
AU - Malatino, L. S.
AU - Zoccali, C.
PY - 1999
Y1 - 1999
N2 - Objective: To investigate the relationship between atherosclerosis, arterial hypertension and other risk factors in uremic patients. Study design: A cross-sectional study in 119 dialysis patients (89 on hemodialysis and 30 on CAPD). Methods: Fasting blood sampling for serum lipids, albumin, hemoglobin, as well as echo-color-Doppler evaluation of common carotid arteries were performed in all patients (during the non-dialysis day in hemodialysis patients). Results: Ninety-five patients had at least one plaque and 57 had at least four plaques. Thirty-eight patients had mild and eleven subjects had severe carotid stenosis. In multiple regression models, the mean internal diameter of carotid arteries correlated to systolic pressure (β=0.36), serum cholesterol (β=-0.25), age (β=0.24) and smoking (β=0.17) (R=0.52, P=0.0001) while the degree of carotid stenosis was predicted by age (β=0.27) and smoking (β=0.23) (R=0.39, P=0.0001). Furthermore, the number of atherosclerotic plaques correlated by age (β=0.35), smoking (β=0.22) and pulse pressure (β=0.18) (R=0.51, P=0.0001) while serum albumin just failed to reach statistical significance (β=-0.16, P=0.06). However, in hemodialysis patients (n=89) serum albumin was a significant and independent predictor of the number of atherosclerotic plaques (β=-0.22). The Kt/Value, duration of dialysis treatment, hemoglobin, serum calcium and phosphate did not add any predictive power to the models. Conclusions: In dialysis patients arterial pressure and smoking are indipendent risk factors of atherosclerosis. Furthermore in hemodialysis patients, serum albumin is an independent predictor of atherosclerosis.
AB - Objective: To investigate the relationship between atherosclerosis, arterial hypertension and other risk factors in uremic patients. Study design: A cross-sectional study in 119 dialysis patients (89 on hemodialysis and 30 on CAPD). Methods: Fasting blood sampling for serum lipids, albumin, hemoglobin, as well as echo-color-Doppler evaluation of common carotid arteries were performed in all patients (during the non-dialysis day in hemodialysis patients). Results: Ninety-five patients had at least one plaque and 57 had at least four plaques. Thirty-eight patients had mild and eleven subjects had severe carotid stenosis. In multiple regression models, the mean internal diameter of carotid arteries correlated to systolic pressure (β=0.36), serum cholesterol (β=-0.25), age (β=0.24) and smoking (β=0.17) (R=0.52, P=0.0001) while the degree of carotid stenosis was predicted by age (β=0.27) and smoking (β=0.23) (R=0.39, P=0.0001). Furthermore, the number of atherosclerotic plaques correlated by age (β=0.35), smoking (β=0.22) and pulse pressure (β=0.18) (R=0.51, P=0.0001) while serum albumin just failed to reach statistical significance (β=-0.16, P=0.06). However, in hemodialysis patients (n=89) serum albumin was a significant and independent predictor of the number of atherosclerotic plaques (β=-0.22). The Kt/Value, duration of dialysis treatment, hemoglobin, serum calcium and phosphate did not add any predictive power to the models. Conclusions: In dialysis patients arterial pressure and smoking are indipendent risk factors of atherosclerosis. Furthermore in hemodialysis patients, serum albumin is an independent predictor of atherosclerosis.
KW - Albumin
KW - Atherosclerosis
KW - Chronic renal failure
KW - Dialysis
KW - Hypertension
KW - Malnutrition
KW - Pulse pressure
KW - Serum total cholesterol
KW - Smoking
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M3 - Article
AN - SCOPUS:0032745347
SN - 0393-5590
VL - 16
SP - 157
EP - 161
JO - Giornale Italiano di Nefrologia
JF - Giornale Italiano di Nefrologia
IS - 2
ER -