I1 fumo, la pressione arteriosa e l'albuminemia sono fattori predittivi indipendenti del danno vascolare negli uremici in dialisi

Translated title of the contribution: Smoking, arterial pressure and serum albumin are independent predictive factors of atherosclerosis in hemodialysis patients

F. A. Benedetto, I. Bellanuova, G. Caridi, F. Rapisarda, P. Fatuzzo, G. Bonanno, G. Seminara, A. Cataliotti, B. Stancanelli, S. Cutrupi, S. Parlongo, F. Mallamaci, G. Tripepi, C. Marino, V. Panuccio, V. Candela, M. Garozzo, F. Tassone, C. Labate, L. S. MalatinoC. Zoccali

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the relationship between atherosclerosis, arterial hypertension and other risk factors in uremic patients. Study design: A cross-sectional study in 119 dialysis patients (89 on hemodialysis and 30 on CAPD). Methods: Fasting blood sampling for serum lipids, albumin, hemoglobin, as well as echo-color-Doppler evaluation of common carotid arteries were performed in all patients (during the non-dialysis day in hemodialysis patients). Results: Ninety-five patients had at least one plaque and 57 had at least four plaques. Thirty-eight patients had mild and eleven subjects had severe carotid stenosis. In multiple regression models, the mean internal diameter of carotid arteries correlated to systolic pressure (β=0.36), serum cholesterol (β=-0.25), age (β=0.24) and smoking (β=0.17) (R=0.52, P=0.0001) while the degree of carotid stenosis was predicted by age (β=0.27) and smoking (β=0.23) (R=0.39, P=0.0001). Furthermore, the number of atherosclerotic plaques correlated by age (β=0.35), smoking (β=0.22) and pulse pressure (β=0.18) (R=0.51, P=0.0001) while serum albumin just failed to reach statistical significance (β=-0.16, P=0.06). However, in hemodialysis patients (n=89) serum albumin was a significant and independent predictor of the number of atherosclerotic plaques (β=-0.22). The Kt/Value, duration of dialysis treatment, hemoglobin, serum calcium and phosphate did not add any predictive power to the models. Conclusions: In dialysis patients arterial pressure and smoking are indipendent risk factors of atherosclerosis. Furthermore in hemodialysis patients, serum albumin is an independent predictor of atherosclerosis.

Translated title of the contributionSmoking, arterial pressure and serum albumin are independent predictive factors of atherosclerosis in hemodialysis patients
Original languageItalian
Pages (from-to)157-161
Number of pages5
JournalGiornale Italiano di Nefrologia
Volume16
Issue number2
StatePublished - Jan 1 1999

Keywords

  • Albumin
  • Atherosclerosis
  • Chronic renal failure
  • Dialysis
  • Hypertension
  • Malnutrition
  • Pulse pressure
  • Serum total cholesterol
  • Smoking

ASJC Scopus subject areas

  • Medicine(all)

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