Smallpox vaccines for biodefense

Richard B. Kennedy; Inna Ovsyannikova; Gregory A. Poland

doi:10.1016/j.vaccine.2009.07.103

Smallpox vaccines for biodefense

Richard B. Kennedy, Inna Ovsyannikova, Gregory A. Poland

General Internal Medicine

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Few diseases can match the enormous impact that smallpox has had on mankind. Its influence can be seen in the earliest recorded histories of ancient civilizations in Egypt and Mesopotamia. With fatality rates up to 30%, smallpox left its survivors with extensive scarring and other serious sequelae. It is estimated that smallpox killed 500 million people in the 19th and 20th centuries. Given the ongoing concerns regarding the use of variola as a biological weapon, this review will focus on the licensed vaccines as well as current research into next-generation vaccines to protect against smallpox and other poxviruses.

Original language	English (US)
Pages (from-to)	D73-D79
Journal	Vaccine
Volume	27
Issue number	SUPPL. 4
DOIs	https://doi.org/10.1016/j.vaccine.2009.07.103
State	Published - Nov 5 2009

Keywords

Biodefense
Smallpox vaccine
Vaccinia virus
Variola virus

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2009.07.103

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KW - Vaccinia virus

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Smallpox vaccines for biodefense

Abstract

Keywords

ASJC Scopus subject areas

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