Sleep apnea, sleep duration and brain mri markers of cerebral vascular disease and Alzheimer's disease: The atherosclerosis risk in communities study (ARIC)

Pamela L. Lutsey, Faye L. Norby, Rebecca F. Gottesman, Thomas Mosley, Richard F. MacLehose, Naresh M. Punjabi, Eyal Shahar, Clifford R Jr. Jack, Alvaro Alonso

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background A growing body of literature has suggested that obstructive sleep apnea (OSA) and habitual short sleep duration are linked to poor cognitive function. Neuroimaging studies may provide insight into this relation. Objective We tested the hypotheses that OSA and habitual short sleep duration, measured at ages 54-73 years, would be associated with adverse brain morphology at ages 67-89 years. Methods Included in this analysis are 312 ARIC study participants who underwent in-home overnight polysomnography in 1996-1998 and brain MRI scans about 15 years later (2012-2013). Sleep apnea was quantified by the apnea-hypopnea index and categorized as moderate/ severe (≥15.0 events/hour), mild (5.0-14.9 events/hour), or normal (

Original languageEnglish (US)
Article numbere0158758
JournalPLoS One
Volume11
Issue number7
DOIs
StatePublished - Jul 1 2016

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cerebrovascular disorders
sleep apnea
Sleep Apnea Syndromes
Obstructive Sleep Apnea
Alzheimer disease
sleep
atherosclerosis
Vascular Diseases
Brain
Atherosclerosis
Alzheimer Disease
Sleep
brain
duration
Polysomnography
Apnea
Neuroimaging
Cognition
apnea
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Lutsey, P. L., Norby, F. L., Gottesman, R. F., Mosley, T., MacLehose, R. F., Punjabi, N. M., ... Alonso, A. (2016). Sleep apnea, sleep duration and brain mri markers of cerebral vascular disease and Alzheimer's disease: The atherosclerosis risk in communities study (ARIC). PLoS One, 11(7), [e0158758]. https://doi.org/10.1371/journal.pone.0158758

Sleep apnea, sleep duration and brain mri markers of cerebral vascular disease and Alzheimer's disease : The atherosclerosis risk in communities study (ARIC). / Lutsey, Pamela L.; Norby, Faye L.; Gottesman, Rebecca F.; Mosley, Thomas; MacLehose, Richard F.; Punjabi, Naresh M.; Shahar, Eyal; Jack, Clifford R Jr.; Alonso, Alvaro.

In: PLoS One, Vol. 11, No. 7, e0158758, 01.07.2016.

Research output: Contribution to journalArticle

Lutsey, Pamela L. ; Norby, Faye L. ; Gottesman, Rebecca F. ; Mosley, Thomas ; MacLehose, Richard F. ; Punjabi, Naresh M. ; Shahar, Eyal ; Jack, Clifford R Jr. ; Alonso, Alvaro. / Sleep apnea, sleep duration and brain mri markers of cerebral vascular disease and Alzheimer's disease : The atherosclerosis risk in communities study (ARIC). In: PLoS One. 2016 ; Vol. 11, No. 7.
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