SLC5 sodium-anion cotransporters and renal urate transport

David B. Mount, Charles Y. Kwon, Consuelo Plata, Michael F. Romero, Kambiz Zandi-Nejad

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Renal urate transport plays a key role in determining the concentration of circulating uric acid. The reabsorption of filtered urate by the renal proximal tubule appears to require apical sodium-dependent anion transport and the apical URAT1 urate-anion exchanger, in that sodium-dependent transport of lactate, ketoacids, nicotinate, and pyrazinoate (PZA) increases the intracellular concentration of substrates for the subsequent exchange with luminal urate. We have identified SLC5A8 and SLC5A12 as candidates for the sodium-anion cotransporter that collaborates with URAT1. Both transporters function as sodium-dependent nicotinate/ monocarboxylate/PZA transporters. Localization studies reveal serial co-expression of these transporters with URAT1, with Slc5a12 in the early proximal tubule and Slc5a8 in S2 and S3 segments. Renal urate excretion is conceivably affected by changes in the activity of SLC5A8, SLC5A12, and/or URAT1, with implications for the pathogenesis of hyperuricemia, nephrolithiasis, and related disorders.

Original languageEnglish (US)
Title of host publicationRENAL STONE DISEASE
Subtitle of host publication1st Annual International Urolithiasis Research Symposium
PublisherAmerican Institute of Physics Inc.
Pages149-158
Number of pages10
ISBN (Print)0735404062, 9780735404069
DOIs
StatePublished - Jan 1 2007
Event1st Annual International Urolithiasis Research Symposium - Indianapolis, IN, United States
Duration: Nov 2 2006Nov 3 2006

Publication series

NameAIP Conference Proceedings
Volume900
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other1st Annual International Urolithiasis Research Symposium
CountryUnited States
CityIndianapolis, IN
Period11/2/0611/3/06

Keywords

  • Hyperuricemia; URAT1
  • Solute carrier family 5; PZA. Pyrazinoate; nicotinate; probenicid; benzbromarone
  • Urate transporter-1; SLC5

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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  • Cite this

    Mount, D. B., Kwon, C. Y., Plata, C., Romero, M. F., & Zandi-Nejad, K. (2007). SLC5 sodium-anion cotransporters and renal urate transport. In RENAL STONE DISEASE: 1st Annual International Urolithiasis Research Symposium (pp. 149-158). (AIP Conference Proceedings; Vol. 900). American Institute of Physics Inc.. https://doi.org/10.1063/1.2723571